| Literature DB >> 29286660 |
Tonghan Zhu1, Zhenyu Lu1, Jie Fan1, Liping Wang1,2, Guoliang Zhu1, Yi Wang1, Xia Li3, Kui Hong4, Pawinee Piyachaturawat5, Arthit Chairoungdua5, Weiming Zhu1.
Abstract
Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC50 values ranging from 0.6 to 9.5 μM.Entities:
Mesh：
Substances：
Year: 2017 PMID： 29286660 DOI： 10.1021/acs.jnatprod.7b00335
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050