Jie Wang1, Weihao Li1, Jiayu Sun2, Hong Liu1, Yu Kang1, Dan Yang1, Liuyu Yu1, Andreas Greiser3, Xiaoyue Zhou4, Yuchi Han5, Yucheng Chen1. 1. Department of Cadiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. 2. Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. 3. Siemens Healthcare, Erlangen, Germany. 4. Siemens Healthcare, Shanghai, China. 5. Department of Medicine (Cardiovascular Division), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
BACKGROUND: Segmental myocardial strain using feature tracking (FT) cardiac MRI is not acceptable due to poor reproducibility. PURPOSE: To assess the reproducibility of left ventricle (LV) segmental myocardial strain measured by deformation registration algorithm (DRA). STUDY TYPE: Prospective clinical trial. SUBJECTS: Sixteen healthy volunteers and 28 hypertrophic cardiomyopathy (HCM) patients. FIELD STRENGTH/SEQUENCE: Retrospective ECG gating cardiac MRI imaging was performed at 3.0T with a steady-state free precession (SSFP) sequence. ASSESSMENT: LV global and segmental myocardial strains were analyzed by DRA, FT, and speckle tracking echocardiography (STE) by two experienced observers and the reproducibility of global and segmental strains were compared. STATISTICAL TESTS: Reproducibility was tested by coefficient of variation (COV) and intraclass correlation coefficient (ICC). Receiver operator curves as well as comparison of areas under the curve (AUC) were analyzed. RESULTS: DRA showed the best observer agreement on segmental strain evaluated by ICC, LS (longitudinal strain): intraobserver variability range (0.98,1.00), interobserver variability range (0.83,0.92), CS (circumferential strain): intraobserver variability range (0.90,0.99), interobserver variability range (0.80,0.97), RS (radial strain): intraobserver variability range (0.84,0.99), interobserver variability range (0.85,0.99). Segmental LS, CS, and RS agreements evaluated by COV for FT and STE were poor. LV global myocardial strain of HCM was significantly lower than controls for all applied techniques, but global CS by DRA had better accuracy compared to FT or STE for distinguishing HCM from healthy subjects: AUC 0.880 (DRA) vs. 0.577 (FT) or 0.736 (STE), P < 0.05. DATA CONCLUSIONS: DRA is a reliable and robust analysis tool for segmental myocardial strain. Global CS by DRA allows discrimination between HCM and normal controls with better accuracy compared with FT and STE. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2018;48:404-414.
BACKGROUND: Segmental myocardial strain using feature tracking (FT) cardiac MRI is not acceptable due to poor reproducibility. PURPOSE: To assess the reproducibility of left ventricle (LV) segmental myocardial strain measured by deformation registration algorithm (DRA). STUDY TYPE: Prospective clinical trial. SUBJECTS: Sixteen healthy volunteers and 28 hypertrophic cardiomyopathy (HCM) patients. FIELD STRENGTH/SEQUENCE: Retrospective ECG gating cardiac MRI imaging was performed at 3.0T with a steady-state free precession (SSFP) sequence. ASSESSMENT: LV global and segmental myocardial strains were analyzed by DRA, FT, and speckle tracking echocardiography (STE) by two experienced observers and the reproducibility of global and segmental strains were compared. STATISTICAL TESTS: Reproducibility was tested by coefficient of variation (COV) and intraclass correlation coefficient (ICC). Receiver operator curves as well as comparison of areas under the curve (AUC) were analyzed. RESULTS:DRA showed the best observer agreement on segmental strain evaluated by ICC, LS (longitudinal strain): intraobserver variability range (0.98,1.00), interobserver variability range (0.83,0.92), CS (circumferential strain): intraobserver variability range (0.90,0.99), interobserver variability range (0.80,0.97), RS (radial strain): intraobserver variability range (0.84,0.99), interobserver variability range (0.85,0.99). Segmental LS, CS, and RS agreements evaluated by COV for FT and STE were poor. LV global myocardial strain of HCM was significantly lower than controls for all applied techniques, but global CS by DRA had better accuracy compared to FT or STE for distinguishing HCM from healthy subjects: AUC 0.880 (DRA) vs. 0.577 (FT) or 0.736 (STE), P < 0.05. DATA CONCLUSIONS:DRA is a reliable and robust analysis tool for segmental myocardial strain. Global CS by DRA allows discrimination between HCM and normal controls with better accuracy compared with FT and STE. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2018;48:404-414.
Authors: Filipa Valente; Laura Gutierrez; Lucia Rodríguez-Eyras; Rúben Fernandez; Maria Montano; Augusto Sao-Aviles; Victor Pineda; Andrea Guala; Hug Cuéllar; Arturo Evangelista; José Rodríguez-Palomares Journal: Int J Cardiol Heart Vasc Date: 2020-06-11
Authors: Jie Wang; Laura Bravo; Jinquan Zhang; Wen Liu; Ke Wan; Jiayu Sun; Yanjie Zhu; Yuchi Han; Georgios V Gkoutos; Yucheng Chen Journal: Front Cardiovasc Med Date: 2021-12-10