Literature DB >> 29282291

Regulation of redox balance in cancer and T cells.

Hyewon Kong1, Navdeep S Chandel2.   

Abstract

Reactive oxygen species (ROS) mediate redox signaling necessary for numerous cellular functions. Yet, high levels of ROS in cells and tissues can cause damage and cell death. Therefore, regulation of redox homeostasis is essential for ROS-dependent signaling that does not incur cellular damage. Cells achieve this optimal balance by coordinating ROS production and elimination. In this Minireview, we discuss the mechanisms by which proliferating cancer and T cells maintain a carefully controlled redox balance. Greater insight into such redox biology may enable precisely targeted manipulation of ROS for effective medical therapies against cancer or immunological disorders.
© 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  T-cell; cancer; reactive oxygen species (ROS); redox regulation; redox signaling

Mesh：

Substances：

Year:  2017        PMID： 29282291      PMCID： PMC5961053          DOI： 10.1074/jbc.TM117.000257

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  98 in total

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Journal:  Sci Signal       Date:  2010-08-03       Impact factor: 8.192

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Journal:  Immunity       Date:  2011-12-23       Impact factor: 31.745

4.  Ferroptosis as a p53-mediated activity during tumour suppression.

Authors:  Le Jiang; Ning Kon; Tongyuan Li; Shang-Jui Wang; Tao Su; Hanina Hibshoosh; Richard Baer; Wei Gu
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5.  Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology.

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Journal:  Cancer Res       Date:  2007-01-15       Impact factor: 12.701

6.  Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.

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Journal:  Cell Metab       Date:  2016-09-22       Impact factor: 27.287

7.  Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

Authors:  Benjamin Yazdanpanah; Katja Wiegmann; Vladimir Tchikov; Oleg Krut; Carola Pongratz; Michael Schramm; Andre Kleinridders; Thomas Wunderlich; Hamid Kashkar; Olaf Utermöhlen; Jens C Brüning; Stefan Schütze; Martin Krönke
Journal:  Nature       Date:  2009-07-29       Impact factor: 49.962

Review 8.  ROS-dependent signal transduction.

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Authors:  Brian N Chorley; Michelle R Campbell; Xuting Wang; Mehmet Karaca; Deepa Sambandan; Fatu Bangura; Peng Xue; Jingbo Pi; Steven R Kleeberger; Douglas A Bell
Journal:  Nucleic Acids Res       Date:  2012-05-11       Impact factor: 16.971

10.  Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

Authors:  Yumiko Imai; Keiji Kuba; G Greg Neely; Rubina Yaghubian-Malhami; Thomas Perkmann; Geert van Loo; Maria Ermolaeva; Ruud Veldhuizen; Y H Connie Leung; Hongliang Wang; Haolin Liu; Yang Sun; Manolis Pasparakis; Manfred Kopf; Christin Mech; Sina Bavari; J S Malik Peiris; Arthur S Slutsky; Shizuo Akira; Malin Hultqvist; Rikard Holmdahl; John Nicholls; Chengyu Jiang; Christoph J Binder; Josef M Penninger
Journal:  Cell       Date:  2008-04-18       Impact factor: 41.582
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  51 in total

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Authors:  Michael M Dubreuil; David W Morgens; Kanji Okumoto; Masanori Honsho; Kévin Contrepois; Brittany Lee-McMullen; Gavin McAllister Traber; Ria S Sood; Scott J Dixon; Michael P Snyder; Yukio Fujiki; Michael C Bassik
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2.  Introduction to the Thematic Minireview Series: Redox metabolism and signaling.

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Journal:  J Biol Chem       Date:  2018-04-05       Impact factor: 5.157

Review 3.  Acetate Metabolism in Physiology, Cancer, and Beyond.

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Journal:  Trends Cell Biol       Date:  2019-05-31       Impact factor: 20.808

4.  Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox.

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Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-02       Impact factor: 11.205

5.  Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers.

Authors:  Suman Mukhopadhyay; Debanjan Goswami; Pavan P Adiseshaiah; William Burgan; Ming Yi; Theresa M Guerin; Serguei V Kozlov; Dwight V Nissley; Frank McCormick
Journal:  Cancer Res       Date:  2020-01-07       Impact factor: 12.701

Review 6.  Use of cucurbitacins for lung cancer research and therapy.

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7.  Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy.

Authors:  Ramon I Klein Geltink; Joy Edwards-Hicks; Petya Apostolova; David O'Sullivan; David E Sanin; Annette E Patterson; Daniel J Puleston; Nina A M Ligthart; Joerg M Buescher; Katarzyna M Grzes; Agnieszka M Kabat; Michal Stanczak; Jonathan D Curtis; Fabian Hässler; Franziska M Uhl; Mario Fabri; Robert Zeiser; Edward J Pearce; Erika L Pearce
Journal:  Nat Metab       Date:  2020-08-03

8.  Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.

Authors:  Henry Kurniawan; Davide G Franchina; Luana Guerra; Lynn Bonetti; Leticia Soriano -Baguet; Melanie Grusdat; Lisa Schlicker; Oliver Hunewald; Catherine Dostert; Myriam P Merz; Carole Binsfeld; Gordon S Duncan; Sophie Farinelle; Yannic Nonnenmacher; Jillian Haight; Dennis Das Gupta; Anouk Ewen; Rabia Taskesen; Rashi Halder; Ying Chen; Christian Jäger; Markus Ollert; Paul Wilmes; Vasilis Vasiliou; Isaac S Harris; Christiane B Knobbe-Thomsen; Jonathan D Turner; Tak W Mak; Michael Lohoff; Johannes Meiser; Karsten Hiller; Dirk Brenner
Journal:  Cell Metab       Date:  2020-03-25       Impact factor: 27.287

9.  Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death.

Authors:  Harry A Rogoff; James D Watson; David A Tuveson; Fieke E M Froeling; Manojit Mosur Swamynathan; Astrid Deschênes; Iok In Christine Chio; Erin Brosnan; Melissa A Yao; Priya Alagesan; Matthew Lucito; Juying Li; An-Yun Chang; Lloyd C Trotman; Pascal Belleau; Youngkyu Park
Journal:  Clin Cancer Res       Date:  2019-09-16       Impact factor: 12.531

10.  Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence.

Authors:  Lucia Xiang; Maria Fernanda Laranjeira-Silva; Fernando Y Maeda; Jason Hauzel; Norma W Andrews; Bidyottam Mittra
Journal:  Infect Immun       Date:  2019-11-18       Impact factor: 3.441
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