Soumaya Ben Khedher1, Monica Neri1, Florence Guida1,2, Mireille Matrat1,3,4, Sylvie Cenée1, Marie Sanchez1, Loredana Radoi1,5, Gwenn Menvielle6, Emilie Marrer7, Danièle Luce8,9, Isabelle Stücker1. 1. CESP, Fac. de Médecine-Univ. Paris-Sud, Fac. de Médecine-UVSQ, INSERM, Université Paris-Saclay, Villejuif, France. 2. International Agency for Research on Cancer (IARC), Lyon Cedex 08, France. 3. Faculty of Medicine IFR 10, University Paris Est-Créteil, Créteil Cedex, France. 4. Centre Hospitalier Intercommunal, Service de Pneumologie et de Pathologie Professionnelle, Créteil Cedex, France. 5. Faculty of Dental Surgery, University Paris Descartes, Paris, France. 6. Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France. 7. Haut-Rhin Cancer Registry, Mulhouse, France. 8. INSERM, U 1085_IRSET, Pointe-à-Pitre, France. 9. University of Rennes 1, Rennes, France.
Abstract
BACKGROUND: To investigate the association of lung cancer with occupational exposure to textile dust and specifically to cotton dust in the population-based case-control study ICARE. METHODS: Lifelong occupational history of 2926 cases and 3555 controls was collected using standardized questionnaires, with specific questions for textile dust exposure. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models controlling for confounding factors including smoking and asbestos exposure. RESULTS: An inverse association between textile dust exposure and lung cancer was found among workers exposed ≥5% of their work time (OR = 0.80, 95%CI = 0.58-1.09), more pronounced for distant exposures (40+ years; up to a 56% reduced risk, statistically significant). The OR of lung cancer was significantly decreased among workers exposed to cotton fibers (OR = 0.70, 95%CI = 0.48-0.97). CONCLUSIONS: Our results provide some evidence of a decreased risk of lung cancer associated with exposure to textile dust, particularly cotton.
BACKGROUND: To investigate the association of lung cancer with occupational exposure to textile dust and specifically to cotton dust in the population-based case-control study ICARE. METHODS: Lifelong occupational history of 2926 cases and 3555 controls was collected using standardized questionnaires, with specific questions for textile dust exposure. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models controlling for confounding factors including smoking and asbestos exposure. RESULTS: An inverse association between textile dust exposure and lung cancer was found among workers exposed ≥5% of their work time (OR = 0.80, 95%CI = 0.58-1.09), more pronounced for distant exposures (40+ years; up to a 56% reduced risk, statistically significant). The OR of lung cancer was significantly decreased among workers exposed to cotton fibers (OR = 0.70, 95%CI = 0.48-0.97). CONCLUSIONS: Our results provide some evidence of a decreased risk of lung cancer associated with exposure to textile dust, particularly cotton.