| Literature DB >> 29279122 |
Mamoni Dash1, Sangram K Samal2, Andrea Morelli3, Cristina Bartoli3, Heidi A Declercq4, Timothy E L Douglas5, Peter Dubruel6, Federica Chiellini3.
Abstract
Polyelectrolyte complexes (PEC) of chitosan and ulvan were fabricated to study alkaline phosphatase (ALP) mediated formation of apatitic minerals. Scaffolds of the PEC were subjected to ALP and successful mineral formation was studied using SEM, Raman and XRD techniques. Investigation of the morphology via SEM shows globular structures of the deposited minerals, which promoted cell attachment, proliferation and extracellular matrix formation. The PEC and their successful calcium phosphate based mineralization offers a greener route of scaffold fabrication towards developing resorbable materials for tissue engineering.Entities:
Keywords: Alkaline phosphatase; Biomimetic mineralization; Chitosan; Enzyme; Polyelectrolyte complexes; Scaffolds; Ulvan
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Year: 2017 PMID： 29279122 DOI： 10.1016/j.carbpol.2017.11.016
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381