Literature DB >> 29278835

Single stage treatment of diabetic calcaneal osteomyelitis with an absorbable gentamicin-loaded calcium sulphate/hydroxyapatite biocomposite: The Silo technique.

Efstathios Drampalos1, Hasan Raza Mohammad2, Chris Kosmidis3, Moez Balal4, Jason Wong5, Anand Pillai6.   

Abstract

BACKGROUND: Chronic osteomyelitis necessities appropriate infected bone and soft tissue excision. The authors describe the Silo surgical technique for the treatment of calcaneal osteomyelitis using a new antibiotic-loaded absorbable calcium sulphate/hydroxyapatite biocomposite.
METHODS: The Silo method involves debridement of the dead bone and local delivery of antibiotic in drilled tunnels using the biocomposite. It is combined with multiple sampling and culture-specific systemic antibiotic treatment guided by a multidisciplinary team. Twelve consecutive diabetic patients with heel ulcers and calcaneal osteomyelitis were treated with the above method. All had comorbidities (Cierny-Mader (C-M) Class B hosts). The mean age was 68 years (range 50-85). A retrospective review of radiographs and electronic medical records was conducted.
RESULTS: Patients were followed up until clinical cure of the ulcer for a mean of 16 weeks (range 12-18). Infection was eradicated in all 12 patients with a single stage procedure following a bone preserving technique. One patient required a subsequent flap operation and six vacuum-assisted closure (V.A.C.). There was also one case of prolonged wound leakage and no calcaneal fractures.
CONCLUSIONS: The Silo technique is an effective method of local delivery of antibiotics and can be effectively implemented into the single-stage treatment of calcaneal osteomyelitis offering increased bone preservation and local delivery of antibiotic, decreasing the need for a major amputation. LEVEL OF EVIDENCE: Level IV- case series. Crown
Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Calcaneal osteomyelitis; Calcium sulphate/hydroxyapatite biocomposite; Silo technique

Mesh:

Substances:

Year:  2017        PMID: 29278835     DOI: 10.1016/j.foot.2017.11.011

Source DB:  PubMed          Journal:  Foot (Edinb)        ISSN: 0958-2592


  8 in total

1.  Medium-term outcomes of multi-disciplinary surgical management of non-ischemic diabetic heel ulcers.

Authors:  Ngwe Phyo; Wegin Tang; Venu Kavarthapu
Journal:  J Clin Orthop Trauma       Date:  2021-01-30

2.  Surgical management of the acute severely infected diabetic foot - The 'infected diabetic foot attack'. An instructional review.

Authors:  R S Ahluwalia; I L H Reichert
Journal:  J Clin Orthop Trauma       Date:  2021-04-24

3.  Surgical Treatment and Outcomes of Calcaneal Osteomyelitis in Adults: A Systematic Review.

Authors:  Marta Sabater-Martos; Irene Katharina Sigmund; Constantinos Loizou; Martin McNally
Journal:  J Bone Jt Infect       Date:  2019-05-21

4.  Surgical Treatment of Diabetic Foot Ulcers Complicated by Osteomyelitis with Gentamicin-Loaded Calcium Sulphate-Hydroxyapatite Biocomposite.

Authors:  Kor H Hutting; Wouter B Aan de Stegge; Jaap J van Netten; Wouter A Ten Cate; Luuk Smeets; Gijs M J M Welten; Dick M Scharn; Jean-Paul P M de Vries; Jeff G van Baal
Journal:  J Clin Med       Date:  2021-01-19       Impact factor: 4.241

Review 5.  Recent advances in the local antibiotics delivery systems for management of osteomyelitis.

Authors:  Reem Khaled Wassif; Maha Elkayal; Rehab Nabil Shamma; Seham A Elkheshen
Journal:  Drug Deliv       Date:  2021-12       Impact factor: 6.819

Review 6.  Local Antibiotic Delivery Systems in Diabetic Foot Osteomyelitis: A Brief Review.

Authors:  Christos Chatzipapas; Makrina Karaglani; Nikolaos Papanas; Konstantinos Tilkeridis; Georgios I Drosos
Journal:  Rev Diabet Stud       Date:  2021-11-01

7.  Multidisciplinary Approach for the Management and Treatment of Diabetic Foot Infections with a Resorbable, Gentamicin-Loaded Bone Graft Substitute.

Authors:  Christine Whisstock; Antonio Volpe; Sasa Ninkovic; Mariagrazia Marin; Marco Meloni; Marino Bruseghin; Giovanni Boschetti; Enrico Brocco
Journal:  J Clin Med       Date:  2020-11-06       Impact factor: 4.241

8.  Single-stage debridement with implantation of antibiotic-loaded calcium sulphate in 34 cases of localized calcaneal osteomyelitis.

Authors:  Nan Jiang; Xing-Qi Zhao; Lei Wang; Qing-Rong Lin; Yan-Jun Hu; Bin Yu
Journal:  Acta Orthop       Date:  2020-04-02       Impact factor: 3.717

  8 in total

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