Literature DB >> 29278213

Biologics in Inflammatory Immune-mediated Systemic Diseases.

Gianluca Moroncini1, Giovanni Calogera1, Devis Benfaremo1, Armando Gabrielli1.   

Abstract

BACKGROUND: The use of biologic agents in systemic immune-mediated diseases has dramatically increased in recent years, replacing conventional immunosuppressive strategies that are characterized by unspecific mechanisms of action and burdened with serious adverse effects. Biologic drugs have selective action towards specific targets, with considerable steroid-sparing effect. They are used nowadays to induce remission or treat specific organ involvements in systemic autoimmune diseases.
CONCLUSION: In this review, we will discuss the scientific evidence supporting the use of biologics in these diseases, with a particular emphasis on their efficacy and safety profile compared to the conventional drugs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  ANCA-associated vasculitis; Behcet Disease; Systemiczzm321990Sclerosis (SSc); Systemic Lupus Erythematosus (SLE); TNF-inhibitors; belimumab; rituximab; tocilizumab

Mesh：

Substances：

Year:  2017        PMID： 29278213     DOI： 10.2174/1389201019666171226152448

Source DB:  PubMed          Journal:  Curr Pharm Biotechnol        ISSN： 1389-2010            Impact factor:   2.837


  5 in total

1.  Pulmonary injury and oxidative stress in rats induced by inhaled sulfur mustard is ameliorated by anti-tumor necrosis factor-α antibody.

Authors:  Rama Malaviya; Alyssa Bellomo; Elena Abramova; Claire R Croutch; Julie Roseman; Rick Tuttle; Eric Peters; Robert P Casillas; Vasanthi R Sunil; Jeffrey D Laskin; Debra L Laskin
Journal:  Toxicol Appl Pharmacol       Date:  2021-08-11       Impact factor: 4.460

2.  Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds.

Authors:  Amy M Zimmermann-Klemd; Jakob K Reinhardt; Anna Morath; Wolfgang W Schamel; Peter Steinberger; Judith Leitner; Roman Huber; Matthias Hamburger; Carsten Gründemann
Journal:  Front Pharmacol       Date:  2020-04-08       Impact factor: 5.810

3.  Disease course in patients with systemic autoimmune diseases: insights on the safety of immunosuppression during the SARS-CoV-2 outbreak in Italy.

Authors:  Devis Benfaremo; Lucia Perini; Valentina Marconi; Michele Maria Luchetti; Armando Gabrielli
Journal:  Eur J Intern Med       Date:  2020-10-15       Impact factor: 4.487

Review 4.  Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches.

Authors:  Devis Benfaremo; Silvia Svegliati; Chiara Paolini; Silvia Agarbati; Gianluca Moroncini
Journal:  Biomedicines       Date:  2022-01-12

Review 5.  Autoimmune Diseases of Digestive Organs-A Multidisciplinary Challenge: A Focus on Hepatopancreatobiliary Manifestation.

Authors:  Lumir Kunovsky; Petr Dite; Petr Jabandziev; Zdenek Kala; Jitka Vaculova; Tomas Andrasina; Matej Hrunka; Martina Bojkova; Jan Trna
Journal:  J Clin Med       Date:  2021-12-11       Impact factor: 4.241
  5 in total

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