Juliana Almeida-de-Souza1,2, Rute Santos3,4, Renata Barros5, Sandra Abreu3, Carla Moreira3, Luís Lopes3, Jorge Mota3, Pedro Moreira5,6. 1. School of Health, Polytechnic Institute of Bragança, Bragança, Portugal. julianaalmeida@ipb.pt. 2. Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal. julianaalmeida@ipb.pt. 3. Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal. 4. Early Start Research Institute, University of Wollongong, Wollongong, NSW, Australia. 5. Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal. 6. Institute of Public Health, University of Porto, Porto, Portugal.
Abstract
BACKGROUND/ OBJECTIVES: The dietary inflammatory index (DII) is a tool to measure the diet's inflammatory potential and has been used with adults to predict low-grade inflammation. The present study aims to assess whether this dietary score predicts low-grade inflammation in adolescents. SUBJECTS/ METHODS: The sample comprises 329 adolescents (55.9% girls), aged 12-18 years, from LabMed Physical Activity Study. DII score was calculated based on a food-frequency questionnaire and categorized into tertiles. We collected blood samples to determine the follow inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), complement component 3 (C3), and 4 (C4). In addition we calculated an overall inflammatory biomarker score. Odds ratios (OR) and 95% confidence intervals (95%CI) were computed from binary logistic regression models. RESULTS: DII score, comparing first with third tertile, was positively associated with IL-6 in crude model (OR = 1.88, 95%CI:1.09-3.24, p trend = 0.011) and in fully adjusted (for biological and lifestyle variables) (OR = 3.38, 95%CI:1.24-9.20, p trend = 0.023). Also, DII score was positively associated with C4, when fully adjusted (OR = 3.12, 95%CI:1.21-8.10, p trend = 0.016). DII score was negatively associated with C3 in crude model, comparing first with second but not with third tertile, and no significant associations in fully adjusted model were observed, although a trend was found (OR = 1.71, 95%CI:0.63-4.66, p trend = 0.044). No significant associations were observed between DII score and CRP. However, DII score was positively associated with the overall inflammatory biomarker score, when fully adjusted (OR = 5.61, 95%CI:2.00-15.78, p trend = 0.002). CONCLUSIONS: DII score can be useful to assess the diet's inflammatory potential and its association with low-grade inflammation in adolescents.
BACKGROUND/ OBJECTIVES: The dietary inflammatory index (DII) is a tool to measure the diet's inflammatory potential and has been used with adults to predict low-grade inflammation. The present study aims to assess whether this dietary score predicts low-grade inflammation in adolescents. SUBJECTS/ METHODS: The sample comprises 329 adolescents (55.9% girls), aged 12-18 years, from LabMed Physical Activity Study. DII score was calculated based on a food-frequency questionnaire and categorized into tertiles. We collected blood samples to determine the follow inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), complement component 3 (C3), and 4 (C4). In addition we calculated an overall inflammatory biomarker score. Odds ratios (OR) and 95% confidence intervals (95%CI) were computed from binary logistic regression models. RESULTS: DII score, comparing first with third tertile, was positively associated with IL-6 in crude model (OR = 1.88, 95%CI:1.09-3.24, p trend = 0.011) and in fully adjusted (for biological and lifestyle variables) (OR = 3.38, 95%CI:1.24-9.20, p trend = 0.023). Also, DII score was positively associated with C4, when fully adjusted (OR = 3.12, 95%CI:1.21-8.10, p trend = 0.016). DII score was negatively associated with C3 in crude model, comparing first with second but not with third tertile, and no significant associations in fully adjusted model were observed, although a trend was found (OR = 1.71, 95%CI:0.63-4.66, p trend = 0.044). No significant associations were observed between DII score and CRP. However, DII score was positively associated with the overall inflammatory biomarker score, when fully adjusted (OR = 5.61, 95%CI:2.00-15.78, p trend = 0.002). CONCLUSIONS: DII score can be useful to assess the diet's inflammatory potential and its association with low-grade inflammation in adolescents.
Authors: Lara Gomes Suhett; H H M Hermsdorff; Sarah Aparecida Vieira Ribeiro; Mariana De Santis Filgueiras; Nitin Shivappa; James R Hébert; Juliana Farias de Novaes Journal: Eur J Nutr Date: 2021-02-11 Impact factor: 5.614
Authors: Sofia Barragán-Vázquez; Ana Carolina Ariza; Ivonne Ramírez Silva; Lilia Susana Pedraza; Juan A Rivera Dommarco; Eduardo Ortiz-Panozo; Elena Zambrano; Luis A Reyes Castro; Nitin Shivappa; James R Hébert; Reynaldo Martorell; Aryeh D Stein; Albino Barraza-Villarreal; Isabelle Romieu; Laura Avila-Jiménez; Usha Ramakrishnan Journal: Nutrients Date: 2020-11-27 Impact factor: 5.717
Authors: Melissa Bujtor; Anne I Turner; Susan J Torres; Laura Esteban-Gonzalo; Carmine M Pariante; Alessandra Borsini Journal: Nutrients Date: 2021-01-25 Impact factor: 5.717
Authors: Abeer Ali Aljahdali; Karen E Peterson; Alejandra Cantoral; Edward Ruiz-Narvaez; Martha M Tellez-Rojo; Hyungjin Myra Kim; James R Hébert; Michael D Wirth; Libni A Torres-Olascoaga; Nitin Shivappa; Ana Baylin Journal: Nutrients Date: 2022-02-20 Impact factor: 5.717
Authors: Chandrika J Piyathilake; Suguna Badiga; Ashley R Chappell; Gary L Johanning; Pauline E Jolly Journal: Nutr Res Date: 2021-04-25 Impact factor: 3.315