Noriyuki Okonogi1, Masaru Wakatsuki2, Shingo Kato3, Shintaro Shiba4, Daijiro Kobayashi4, Hiroki Kiyohara5, Kumiko Karasawa6, Tatsuya Ohno4, Takashi Nakano4, Tadashi Kamada7, Makio Shozu8. 1. Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan okonogi.noriyuki@qst.go.jp. 2. Department of Radiology, Jichi Medical University, Tochigi, Japan. 3. Department of Radiation Oncology, Saitama Medical University, International Medical Center, Saitama, Japan. 4. Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan. 5. Department of Radiation Oncology, Maebashi Red Cross Hospital, Maebashi, Japan. 6. Department of Radiation Oncology, Tokyo Women's Medical University, Tokyo, Japan. 7. Hospital, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. 8. Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Abstract
BACKGROUND/AIM: To evaluate the long-term outcomes of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical squamous cell carcinoma (LAC-SqCC) in 2 prospective phase I/II studies. PATIENTS AND METHODS: In the first study, 14 patients were treated with 68.8-72.8 Gy (RBE)/24 fractions. In a subsequent study, 22 patients were treated with 64.0-72.0 Gy (RBE)/20 fractions while limiting the dose to the gastro-intestinal (GI) <60 Gy (RBE). RESULTS: The 10-year local control rates were 92% and 61% for the patients administered a total dose of 72.0-72.8 Gy (RBE) and 64.0-68.8 Gy (RBE), respectively. Two patients in the first study developed grade 3/4 rectal or bladder complications; however, no grade 3 or higher complications occurred in the second study. CONCLUSION: C-ion RT with a higher dose was associated with excellent LC in LAC-SqCC. Long-term safety was confirmed based on the establishment of dose constraints for the GI tract. Copyright
BACKGROUND/AIM: To evaluate the long-term outcomes of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical squamous cell carcinoma (LAC-SqCC) in 2 prospective phase I/II studies. PATIENTS AND METHODS: In the first study, 14 patients were treated with 68.8-72.8 Gy (RBE)/24 fractions. In a subsequent study, 22 patients were treated with 64.0-72.0 Gy (RBE)/20 fractions while limiting the dose to the gastro-intestinal (GI) <60 Gy (RBE). RESULTS: The 10-year local control rates were 92% and 61% for the patients administered a total dose of 72.0-72.8 Gy (RBE) and 64.0-68.8 Gy (RBE), respectively. Two patients in the first study developed grade 3/4 rectal or bladder complications; however, no grade 3 or higher complications occurred in the second study. CONCLUSION: C-ion RT with a higher dose was associated with excellent LC in LAC-SqCC. Long-term safety was confirmed based on the establishment of dose constraints for the GI tract. Copyright
Authors: Nathalie Arians; Nils Henrik Nicolay; Stephan Brons; Stefan Alexander Koerber; Christine Jaschke; Marco Vercruysse; Sigrid Daffinger; Alexander Rühle; Jürgen Debus; Katja Lindel Journal: J Radiat Res Date: 2019-10-23 Impact factor: 2.724