Moya Vandeleur1, Lisa M Walter2, David S Armstrong3, Philip Robinson4, Gillian M Nixon5, Rosemary S C Horne6. 1. The Ritchie Centre, Department of Paediatrics, Monash University and Hudson Institute of Medical Research, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia. 2. The Ritchie Centre, Department of Paediatrics, Monash University and Hudson Institute of Medical Research, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia. 3. The Ritchie Centre, Department of Paediatrics, Monash University and Hudson Institute of Medical Research, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia; Department of Respiratory and Sleep Medicine, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia. 4. Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia. 5. The Ritchie Centre, Department of Paediatrics, Monash University and Hudson Institute of Medical Research, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia; Department of Respiratory and Sleep Medicine, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia; Melbourne Children's Sleep Centre, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia. 6. The Ritchie Centre, Department of Paediatrics, Monash University and Hudson Institute of Medical Research, Monash Children's Hospital, 246 Clayton Road, Melbourne, Victoria 3168, Australia. Electronic address: rosemary.horne@monash.edu.
Abstract
BACKGROUND: We aimed to investigate the relationship between sleep quality, mood and health-related quality of life (HRQOL) in children with CF and controls. METHODS: Children (7-12years) and adolescents (13-18years) with CF and controls completed sleep evaluation: overnight oximetry and 14days of actigraphy. Age-appropriate questionnaires assessed mood (Children's Depression Inventory; CDI or Beck's Depression Inventory), HRQOL (CF Questionnaire-Revised; CFQ-R or PedsQL), and sleepiness (Pediatric Daytime Sleepiness Scale). RESULTS: 87 CF and 55 controls recruited. Children with CF had poorer sleep quality, more sleepiness and lower mood than controls, with a negative correlation between mood score and sleep efficiency. Sleepiness score was predictive of mood score and multiple CFQ-R domains. Adolescents with CF also demonstrated poorer sleep and more sleepiness than controls, but no difference in mood. Reduced sleep quality predicted lower CFQ-R scores. No correlation between sleep, mood or HRQOL in controls. CONCLUSIONS: In children and adolescents with CF, impaired sleep quality is associated with lower mood and HRQOL in an age-specific manner. Future research will aid understanding of effective strategies for prevention and treatment of mood disorders and sleep disturbance in children with CF. Crown
BACKGROUND: We aimed to investigate the relationship between sleep quality, mood and health-related quality of life (HRQOL) in children with CF and controls. METHODS:Children (7-12years) and adolescents (13-18years) with CF and controls completed sleep evaluation: overnight oximetry and 14days of actigraphy. Age-appropriate questionnaires assessed mood (Children's Depression Inventory; CDI or Beck's Depression Inventory), HRQOL (CF Questionnaire-Revised; CFQ-R or PedsQL), and sleepiness (Pediatric Daytime Sleepiness Scale). RESULTS: 87 CF and 55 controls recruited. Children with CF had poorer sleep quality, more sleepiness and lower mood than controls, with a negative correlation between mood score and sleep efficiency. Sleepiness score was predictive of mood score and multiple CFQ-R domains. Adolescents with CF also demonstrated poorer sleep and more sleepiness than controls, but no difference in mood. Reduced sleep quality predicted lower CFQ-R scores. No correlation between sleep, mood or HRQOL in controls. CONCLUSIONS: In children and adolescents with CF, impaired sleep quality is associated with lower mood and HRQOL in an age-specific manner. Future research will aid understanding of effective strategies for prevention and treatment of mood disorders and sleep disturbance in children with CF. Crown
Authors: Joel Reiter; Alex Gileles-Hillel; Malena Cohen-Cymberknoh; Dennis Rosen; Eitan Kerem; David Gozal; Erick Forno Journal: Sleep Med Rev Date: 2020-02-19 Impact factor: 11.609