| Literature DB >> 29277306 |
Takuya Kumamoto1, Marie Nakajima2, Reina Uga2, Naoko Ihayazaka2, Haruna Kashihara2, Kazuaki Katakawa2, Tsutomu Ishikawa3, Ryotaro Saiki3, Kazuhiro Nishimura3, Kazuei Igarashi4.
Abstract
N-Methyl-d-aspartate (NMDA) receptors have been implicated in learning and memory, and may also play a central role in various conditions leading to neuronal degradation. NMDA receptor antagonists could therefore be of therapeutic benefit for a number of neurological disorders. We have designed hybrid compounds of polyamines and memantine, both of which function as NMDA channel blockers. The triamine derivative with a guanidine moiety showed more potent antagonistic activity than memantine.Entities:
Keywords: Alzheimer’s disease; Guanidine; Memantine; NMDA channel blocker; Polyamine
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Year: 2017 PMID： 29277306 DOI： 10.1016/j.bmc.2017.12.021
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641