Marianne Sinding1, David A Peters2, Sofie S Poulsen3, Jens B Frøkjær4, Ole B Christiansen5, Astrid Petersen6, Niels Uldbjerg7, Anne Sørensen8. 1. Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Reberbansgade 15, 9000 Aalborg, Denmark. Electronic address: masore78@hotmail.com. 2. Department of Clinical Engineering, Central Denmark Region, Aarhus, Olof Palmes Alle 13, 8200 Aarhus N, Denmark. Electronic address: David.Peters@stab.rm.dk. 3. Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Reberbansgade 15, 9000 Aalborg, Denmark. 4. Department of Radiology, Aalborg University Hospital, Aalborg, Hobrovej 18-22, 9100 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University Hospital, Sdr. Skovvej 15, 9000 Aalborg, Denmark. Electronic address: jebf@rn.dk. 5. Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Reberbansgade 15, 9000 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University Hospital, Sdr. Skovvej 15, 9000 Aalborg, Denmark. Electronic address: obc@rn.dk. 6. Department of Pathology, Aalborg University Hospital, Aalborg, Reberbansgade 15, 9000 Aalborg, Denmark. Electronic address: acp@rn.dk. 7. Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Palle Juul- Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address: uldbjerg@dadlnet.dk. 8. Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Reberbansgade 15, 9000 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University Hospital, Sdr. Skovvej 15, 9000 Aalborg, Denmark. Electronic address: annenoedgaard@hotmail.com.
Abstract
OBJECTIVES: Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*). METHOD: We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight < 10th percentile in combination with placental pathological signs of vascular malperfusion. During maternal oxygen inhalation, we measured the relative ΔBOLD response ((hyperoxic BOLD - baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute ΔT2* (hyperoxic T2*- baseline T2*) from breath-hold multi-echo GRE sequences. RESULTS: In the control group, the relative ΔBOLD response increased during gestation from 5% in gestational week 20 to 20% in week 40. In the case group, the relative ΔBOLD response was significantly higher (mean Z-score 4.94; 95% CI 2.41, 7.47). The absolute ΔT2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score -3.13; 95% CI -3.94, -2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log10 ΔBOLD response and the baseline T2* (r = -0.88, p < 0.0001). CONCLUSION: The high hyperoxic ΔBOLD response demonstrated in pregnancies complicated by placental dysfunction may simply reflect altered baseline conditions, as the absolute increase in placental oxygenation (ΔT2*) does not differ between groups.
OBJECTIVES:Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*). METHOD: We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight < 10th percentile in combination with placental pathological signs of vascular malperfusion. During maternal oxygen inhalation, we measured the relative ΔBOLD response ((hyperoxic BOLD - baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute ΔT2* (hyperoxic T2*- baseline T2*) from breath-hold multi-echo GRE sequences. RESULTS: In the control group, the relative ΔBOLD response increased during gestation from 5% in gestational week 20 to 20% in week 40. In the case group, the relative ΔBOLD response was significantly higher (mean Z-score 4.94; 95% CI 2.41, 7.47). The absolute ΔT2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score -3.13; 95% CI -3.94, -2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log10 ΔBOLD response and the baseline T2* (r = -0.88, p < 0.0001). CONCLUSION: The high hyperoxic ΔBOLD response demonstrated in pregnancies complicated by placental dysfunction may simply reflect altered baseline conditions, as the absolute increase in placental oxygenation (ΔT2*) does not differ between groups.
Authors: Esra Abaci Turk; Jeffrey N Stout; Christopher Ha; Jie Luo; Borjan Gagoski; Filiz Yetisir; Polina Golland; Lawrence L Wald; Elfar Adalsteinsson; Julian N Robinson; Drucilla J Roberts; William H Barth; P Ellen Grant Journal: Top Magn Reson Imaging Date: 2019-10
Authors: Jeffrey N Stout; Congyu Liao; Borjan Gagoski; Esra Abaci Turk; Henry A Feldman; Carolina Bibbo; William H Barth; Scott A Shainker; Lawrence L Wald; P Ellen Grant; Elfar Adalsteinsson Journal: Placenta Date: 2021-08-24 Impact factor: 3.287
Authors: Matthias C Schabel; Victoria H J Roberts; Karen J Gibbins; Monica Rincon; Jessica E Gaffney; Aaron D Streblow; Adam M Wright; Jamie O Lo; Byung Park; Christopher D Kroenke; Kathryn Szczotka; Nathan R Blue; Jessica M Page; Kathy Harvey; Michael W Varner; Robert M Silver; Antonio E Frias Journal: PLoS One Date: 2022-07-19 Impact factor: 3.752
Authors: Stephanie A Giza; Simran Sethi; Lauren M Smith; Mary-Ellen E T Empey; Lindsay E Morris; Charles A McKenzie Journal: J Dev Orig Health Dis Date: 2020-12-14 Impact factor: 2.401
Authors: Sophie Couper; Alys Clark; John M D Thompson; Dimitra Flouri; Rosalind Aughwane; Anna L David; Andrew Melbourne; Ali Mirjalili; Peter R Stone Journal: J Physiol Date: 2021-01-18 Impact factor: 6.228
Authors: Johannes K Steinweg; Grace Tin Yan Hui; Maximilian Pietsch; Alison Ho; Milou Pm van Poppel; David Lloyd; Kathleen Colford; John M Simpson; Reza Razavi; Kuberan Pushparajah; Mary Rutherford; Jana Hutter Journal: Placenta Date: 2021-03-09 Impact factor: 3.481
Authors: Maximilian Pietsch; Alison Ho; Alessia Bardanzellu; Aya Mutaz Ahmad Zeidan; Lucy C Chappell; Joseph V Hajnal; Mary Rutherford; Jana Hutter Journal: Med Image Anal Date: 2021-06-23 Impact factor: 8.545
Authors: Anita A Harteveld; Jana Hutter; Suzanne L Franklin; Laurence H Jackson; Mary Rutherford; Joseph V Hajnal; Matthias J P van Osch; Clemens Bos; Enrico De Vita Journal: Magn Reson Med Date: 2020-03-06 Impact factor: 3.737