Literature DB >> 29276721

Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays.

Megan M Senchuk1, Dylan J Dues1, Jeremy M Van Raamsdonk1.   

Abstract

Oxidative stress has been proposed to be one of the main causes of aging and has been implicated in the pathogenesis of many diseases. Sensitivity to oxidative stress can be measured by quantifying survival following exposure to a reactive oxygen species (ROS)-generating compound such as paraquat or juglone. Sensitivity to oxidative stress is a balance between basal levels of ROS, the ability to detoxify ROS, and the ability to repair ROS-mediated damage.

Entities:  

Keywords:  C. elegans; Oxidative stress; juglone; paraquat; reactive oxygen species; stress resistance

Year:  2017        PMID： 29276721      PMCID： PMC5739066          DOI： 10.21769/BioProtoc.2086

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  10 in total

1.  FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1.

Authors:  Jeremy Michael Van Raamsdonk; Siegfried Hekimi
Journal:  Mech Ageing Dev       Date:  2011-08-27       Impact factor: 5.432

2.  Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage.

Authors:  Jeremy Michael Van Raamsdonk; Yan Meng; Darius Camp; Wen Yang; Xihua Jia; Claire Bénard; Siegfried Hekimi
Journal:  Genetics       Date:  2010-04-09       Impact factor: 4.562

3.  Superoxide dismutase is dispensable for normal animal lifespan.

Authors:  Jeremy Michael Van Raamsdonk; Siegfried Hekimi
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

4.  Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain.

Authors:  Pablo R Castello; Derek A Drechsel; Manisha Patel
Journal:  J Biol Chem       Date:  2007-03-27       Impact factor: 5.157

5.  The C. elegans healthspan and stress-resistance assay toolkit.

Authors:  Scott Alexander Keith; Francis Raj Gandhi Amrit; Ramesh Ratnappan; Arjumand Ghazi
Journal:  Methods       Date:  2014-04-13       Impact factor: 3.608

6.  Oxidative stress is increased in C. elegans models of Huntington's disease but does not contribute to polyglutamine toxicity phenotypes.

Authors:  Emily Machiela; Dylan J Dues; Megan M Senchuk; Jeremy M Van Raamsdonk
Journal:  Neurobiol Dis       Date:  2016-08-18       Impact factor: 5.996

7.  Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.

Authors:  Claire E Schaar; Dylan J Dues; Katie K Spielbauer; Emily Machiela; Jason F Cooper; Megan Senchuk; Siegfried Hekimi; Jeremy M Van Raamsdonk
Journal:  PLoS Genet       Date:  2015-02-11       Impact factor: 5.917

8.  Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways.

Authors:  Dylan J Dues; Emily K Andrews; Claire E Schaar; Alexis L Bergsma; Megan M Senchuk; Jeremy M Van Raamsdonk
Journal:  Aging (Albany NY)       Date:  2016-04       Impact factor: 5.682

9.  Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.

Authors:  Jeremy M Van Raamsdonk; Siegfried Hekimi
Journal:  PLoS Genet       Date:  2009-02-06       Impact factor: 5.917

10.  Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models.

Authors:  Jason F Cooper; Dylan J Dues; Katie K Spielbauer; Emily Machiela; Megan M Senchuk; Jeremy M Van Raamsdonk
Journal:  NPJ Parkinsons Dis       Date:  2015-11-19
  10 in total
  19 in total

1.  Perfluorooctane Sulfonate (PFOS) Produces Dopaminergic Neuropathology in Caenorhabditis elegans.

Authors:  Shreesh Raj Sammi; Rachel M Foguth; Claudia Sofía Nieves; Chloe De Perre; Peter Wipf; Cynthia T McMurray; Linda S Lee; Jason R Cannon
Journal:  Toxicol Sci       Date:  2019-12-01       Impact factor: 4.849

2.  Tyrosine aminotransferase is involved in the oxidative stress response by metabolizing meta-tyrosine in Caenorhabditis elegans.

Authors:  Brett R Ipson; Rebecca A Green; John T Wilson; Jacob N Watson; Kym F Faull; Alfred L Fisher
Journal:  J Biol Chem       Date:  2019-05-01       Impact factor: 5.157

3.  Hemiterpene compound, 3,3-dimethylallyl alcohol promotes longevity and neuroprotection in Caenorhabditis elegans.

Authors:  Suresh Chandra Phulara; Swapnil Pandey; Anubhuti Jha; Puneet Singh Chauhan; Pratima Gupta; Virendra Shukla
Journal:  Geroscience       Date:  2020-07-28       Impact factor: 7.713

Review 4.  C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration.

Authors:  Francisco José Naranjo-Galindo; Ruixue Ai; Evandro Fei Fang; Hilde Loge Nilsen; Tanima SenGupta
Journal:  Front Aging       Date:  2022-06-22

5.  The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans.

Authors:  Mehul Vora; Stephanie M Pyonteck; Tatiana Popovitchenko; Tarmie L Matlack; Aparna Prashar; Nanci S Kane; John Favate; Premal Shah; Christopher Rongo
Journal:  Nat Commun       Date:  2022-10-18       Impact factor: 17.694

6.  G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.

Authors:  Stacy A Henry; Selina Crivello; Tina M Nguyen; Magdalena Cybulska; Ngoc S Hoang; Mary Nguyen; Tajinder Badial; Nazgol Emami; Nasma Awada; Johnathen F Woodward; Christopher H So
Journal:  Cell Stress Chaperones       Date:  2020-10-16       Impact factor: 3.667

7.  Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways.

Authors:  Emily Machiela; Thomas Liontis; Dylan J Dues; Paige D Rudich; Annika Traa; Leslie Wyman; Corah Kaufman; Jason F Cooper; Leira Lew; Saravanapriah Nadarajan; Megan M Senchuk; Jeremy M Van Raamsdonk
Journal:  FASEB J       Date:  2020-05-08       Impact factor: 5.191

8.  Polydatin relieves paraquat-induced human MRC-5 fibroblast injury through inhibiting the activation of the NLRP3 inflammasome.

Authors:  Yue Fu; Mei Yan; Chunming Xie; Jinlun Hu; Xiangxia Zeng; Qiaohua Hu
Journal:  Ann Transl Med       Date:  2020-06

9.  Polygonum multiflorum Extract Exerts Antioxidative Effects and Increases Life Span and Stress Resistance in the Model Organism Caenorhabditis elegans via DAF-16 and SIR-2.1.

Authors:  Christina Saier; Christian Büchter; Karoline Koch; Wim Wätjen
Journal:  Plants (Basel)       Date:  2018-07-20

10.  Measurements of Physiological Stress Responses in C. Elegans.

Authors:  Raz Bar-Ziv; Ashley E Frakes; Ryo Higuchi-Sanabria; Theodore Bolas; Phillip A Frankino; Holly K Gildea; Melissa G Metcalf; Andrew Dillin
Journal:  J Vis Exp       Date:  2020-05-21       Impact factor: 1.355
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