Literature DB >> 29276074

Kinases: Molecular Stage Directors for Schistosome Development and Differentiation.

Christoph G Grevelding1, Simone Langner2, Colette Dissous3.   

Abstract

Understanding schistosome biology is still a challenging mission. The reproductive biology of this parasitic trematode is closely associated with the pathologic consequences of schistosomiasis, the devastating infectious disease caused by members of the family Schistosomatidae worldwide. Recent studies of signaling mechanisms confirmed the prominent roles of protein kinases (PKs) in directing schistosome biology, and first evidence was obtained for an additional contribution of kinases with substrates different from proteins (non-PKs). This review provides an overview of the Schistosoma mansoni kinome in the context of male-female interaction and summarizes recent studies of kinases controlling development and differentiation. Due to their importance for schistosome biology, kinases represent Achilles' heels and are therefore of high value also for translational research.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Schistosoma mansoni; development and differentiation; gonad; kinase; signal transduction; transcriptomics

Mesh：

Substances：

Year:  2017        PMID： 29276074     DOI： 10.1016/j.pt.2017.12.001

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  14 in total

1.  Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni.

Authors:  Bernardo Pereira Moreira; Izabella Cristina Andrade Batista; Naiara Clemente Tavares; Tom Armstrong; Sandra Grossi Gava; Gabriella Parreiras Torres; Marina Moraes Mourão; Franco H Falcone
Journal:  Front Cell Infect Microbiol       Date:  2022-07-05       Impact factor: 6.073

2.  A male-derived nonribosomal peptide pheromone controls female schistosome development.

Authors:  Rui Chen; Jipeng Wang; Irina Gradinaru; Hieu S Vu; Sophie Geboers; Jacinth Naidoo; Joseph M Ready; Noelle S Williams; Ralph J DeBerardinis; Elliott M Ross; James J Collins
Journal:  Cell       Date:  2022-04-05       Impact factor: 66.850

3.  Evolution of gene dosage on the Z-chromosome of schistosome parasites.

Authors:  Marion A L Picard; Celine Cosseau; Sabrina Ferré; Thomas Quack; Christoph G Grevelding; Yohann Couté; Beatriz Vicoso
Journal:  Elife       Date:  2018-07-25       Impact factor: 8.140

4.  Schistosoma mansoni FES Tyrosine Kinase Involvement in the Mammalian Schistosomiasis Outcome and Miracidia Infection Capability in Biomphalaria glabrata.

Authors:  Naiara Clemente Tavares; Sandra Grossi Gava; Gabriella Parreiras Torres; Clara Ênia Soares de Paiva; Bernardo Pereira Moreira; Felipe Miguel Nery Lunkes; Langia Colli Montresor; Roberta Lima Caldeira; Marina Moraes Mourão
Journal:  Front Microbiol       Date:  2020-06-11       Impact factor: 5.640

5.  Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni.

Authors:  Jipeng Wang; Rui Chen; James J Collins
Journal:  PLoS Biol       Date:  2019-05-08       Impact factor: 8.029

6.  Combination Anthelmintic/Antioxidant Activity Against Schistosoma Mansoni.

Authors:  Maria João Gouveia; Paul J Brindley; Gabriel Rinaldi; Fátima Gärtner; José Manuel Correia da Costa; Nuno Vale
Journal:  Biomolecules       Date:  2019-02-05

Review 7.  Protein Kinases: Potential Drug Targets Against Schistosoma japonicum.

Authors:  Kaijuan Wu; Xingyu Zhai; Shuaiqin Huang; Liping Jiang; Zheng Yu; Jing Huang
Journal:  Front Cell Infect Microbiol       Date:  2021-07-01       Impact factor: 5.293

Review 8.  Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence.

Authors:  José T Moreira-Filho; Arthur C Silva; Rafael F Dantas; Barbara F Gomes; Lauro R Souza Neto; Jose Brandao-Neto; Raymond J Owens; Nicholas Furnham; Bruno J Neves; Floriano P Silva-Junior; Carolina H Andrade
Journal:  Front Immunol       Date:  2021-05-31       Impact factor: 7.561

9.  Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents.

Authors:  Sandra Giuliani; Arthur C Silva; Joyce V V B Borba; Pablo I P Ramos; Ross A Paveley; Eugene N Muratov; Carolina Horta Andrade; Nicholas Furnham
Journal:  PLoS Comput Biol       Date:  2018-10-22       Impact factor: 4.475

10.  Deep phosphoproteome analysis of Schistosoma mansoni leads development of a kinomic array that highlights sex-biased differences in adult worm protein phosphorylation.

Authors:  Natasha L Hirst; Jean-Christophe Nebel; Scott P Lawton; Anthony J Walker
Journal:  PLoS Negl Trop Dis       Date:  2020-03-23
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