Ioannis Panagopoulos1, Ludmila Gorunova2, Kristin Andersen2, Ingvild Lobmaier3, Bodil Bjerkehagen3, Sverre Heim2,4. 1. Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway ioannis.panagopoulos@rr-research.no. 2. Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. 3. Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. 4. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Abstract
BACKGROUND/AIM: Angiolipoma is a rare benign soft tissue tumor composed of mature adipocytes and blood vessels. Genetic information on angiolipomas is scarce. With the single exception of one tumor which carried a t(X;2)(p22;p12), all angiolipomas hitherto investigated cytogenetically had normal karyotypes. MATERIALS AND METHODS: G-banding chromosome analysis was performed on three short-term cultured angiolipomas. Fluorescence in situ hybridization (FISH) analysis using a commercially available RB1 deletion probe was also done. RESULTS: All three angiolipomas had abnormal karyotypes with loss or structural rearrangement of chromosome 13. The first tumor had the karyotype 46,XY,-6,del(13)(q14),+mar[cp5], the second had 44~45,XY,t(1;10;15)(p21~22;q24;q24),-13[cp5], and the third karyotype was 43,XX,t(13;22;17) (q12;q13; q22~23)[14]. FISH analysis showed heterozygous and homozygous deletion of the RB1 probe in case 2 and 3, respectively. FISH analysis failed in case 1. CONCLUSION: Chromosome 13 was consistently involved in all three angiolipomas. Copyright
BACKGROUND/AIM: Angiolipoma is a rare benign soft tissue tumor composed of mature adipocytes and blood vessels. Genetic information on angiolipomas is scarce. With the single exception of one tumor which carried a t(X;2)(p22;p12), all angiolipomas hitherto investigated cytogenetically had normal karyotypes. MATERIALS AND METHODS: G-banding chromosome analysis was performed on three short-term cultured angiolipomas. Fluorescence in situ hybridization (FISH) analysis using a commercially available RB1 deletion probe was also done. RESULTS: All three angiolipomas had abnormal karyotypes with loss or structural rearrangement of chromosome 13. The first tumor had the karyotype 46,XY,-6,del(13)(q14),+mar[cp5], the second had 44~45,XY,t(1;10;15)(p21~22;q24;q24),-13[cp5], and the third karyotype was 43,XX,t(13;22;17) (q12;q13; q22~23)[14]. FISH analysis showed heterozygous and homozygous deletion of the RB1 probe in case 2 and 3, respectively. FISH analysis failed in case 1. CONCLUSION: Chromosome 13 was consistently involved in all three angiolipomas. Copyright
Authors: R Sciot; M Akerman; P Dal Cin; I De Wever; C D Fletcher; N Mandahl; F Mertens; F Mitelman; J Rosai; A Rydholm; G Tallini; H Van den Berghe; R Vanni; H Willen Journal: Am J Surg Pathol Date: 1997-04 Impact factor: 6.394
Authors: Hammurabi Bartuma; Karolin H Nord; Gemma Macchia; Margareth Isaksson; Jenny Nilsson; Henryk A Domanski; Nils Mandahl; Fredrik Mertens Journal: Genes Chromosomes Cancer Date: 2011-05-11 Impact factor: 5.006
Authors: Anna Dahlén; Maria Debiec-Rychter; Florence Pedeutour; Henryk A Domanski; Mattias Höglund; Henrik C F Bauer; Anders Rydholm; Raf Sciot; Nils Mandahl; Fredrik Mertens Journal: Int J Cancer Date: 2003-02-20 Impact factor: 7.396
Authors: N Mandahl; M Höglund; F Mertens; A Rydholm; H Willén; O Brosjö; F Mitelman Journal: Genes Chromosomes Cancer Date: 1994-03 Impact factor: 5.006
Authors: Benjamin J Chen; Adrián Mariño-Enríquez; Christopher D M Fletcher; Jason L Hornick Journal: Am J Surg Pathol Date: 2012-08 Impact factor: 6.394
Authors: Sara Al-Ghadban; Walter Cromer; Marisol Allen; Christopher Ussery; Michael Badowski; David Harris; Karen L Herbst Journal: J Obes Date: 2019-03-03