| Literature DB >> 29275263 |
Jun Ma1, Quanhui Ren1, Bangjian Dong1, Zhaoyu Shi1, Jie Zhang2, Da-Qing Jin3, Jing Xu4, Yasushi Ohizumi5, Dongho Lee6, Yuanqiang Guo7.
Abstract
Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein.Entities:
Keywords: Blumea balsamifera; Diterpenoids; Molecular docking; NO inhibitory activities; Sesquiterpenoids
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Year: 2017 PMID： 29275263 DOI： 10.1016/j.bioorg.2017.12.008
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275