Literature DB >> 29275007

Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon.

Michael P Pollastri1.   

Abstract

Decades after the last new chemical entity was added to the pharmacopeia for human African trypanosomiasis (or sleeping sickness), orally dosed fexinidazole stands poised to replace the current treatment regimen for Trypanosoma brucei gambiense infections, following a positive Phase 2/3 clinical trial.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 29275007      PMCID： PMC5828866          DOI： 10.1016/j.pt.2017.12.002

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  12 in total

1.  Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.

Authors:  Kelly A Bachovchin; Amrita Sharma; Seema Bag; Dana M Klug; Katherine M Schneider; Baljinder Singh; Hitesh B Jalani; Melissa J Buskes; Naimee Mehta; Scott Tanghe; Jeremiah D Momper; Richard J Sciotti; Ana Rodriguez; Kojo Mensa-Wilmot; Michael P Pollastri; Lori Ferrins
Journal:  J Med Chem       Date:  2019-01-10       Impact factor: 7.446

2.  Optimal kinetic exposures for classic and candidate antitrypanosomals.

Authors:  Kirsten J Meyer; David J Meyers; Theresa A Shapiro
Journal:  J Antimicrob Chemother       Date:  2019-08-01       Impact factor: 5.790

3.  Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity.

Authors:  Dana M Klug; Rosario Diaz-Gonzalez; Travis J DeLano; Eftychia M Mavrogiannaki; Melissa J Buskes; Raeann M Dalton; John K Fisher; Katherine M Schneider; Vivian Hilborne; Melanie G Fritsche; Quillon J Simpson; Westley F Tear; William G Devine; Guiomar Pérez-Moreno; Gloria Ceballos-Pérez; Raquel García-Hernández; Cristina Bosch-Navarrete; Luis Miguel Ruiz-Pérez; Francisco Gamarro; Dolores González-Pacanowska; Maria Santos Martinez-Martinez; Pilar Manzano-Chinchon; Miguel Navarro; Michael P Pollastri; Lori Ferrins
Journal:  RSC Med Chem       Date:  2020-07-10

4.  Physiologic Targets and Modes of Action for CBL0137, a Lead for Human African Trypanosomiasis Drug Development.

Authors:  Carlos E Sanz-Rodriguez; Benjamin Hoffman; Paul J Guyett; Andrei Purmal; Baljinder Singh; Michael Pollastri; Kojo Mensa-Wilmot
Journal:  Mol Pharmacol       Date:  2022-05-23       Impact factor: 4.054

5.  Identification of megacerotonic acid and a quinazoline derivative from Universal Natural Product Database as potential inhibitors of Trypanosoma brucei brucei alternative oxidase: molecular docking, molecular dynamic simulation and MM/PBSA analysis.

Authors:  Rahma Muhammad Adamu; Bashiru Ibrahim; Mohammed Auwal Ibrahim; Emmanuel Oluwadare Balogun
Journal:  J Biomol Struct Dyn       Date:  2021-11-23       Impact factor: 5.235

6.  Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness.

Authors:  Ronald W Brown; Ashraf M Abdel-Megeed; Paul A Keller; Amy J Jones; Melissa L Sykes; Marcel Kaiser; Jonathan B Baell; Vicky M Avery; Christopher J T Hyland
Journal:  RSC Med Chem       Date:  2020-09-23

7.  Resolving the apparent transmission paradox of African sleeping sickness.

Authors:  Paul Capewell; Katie Atkins; William Weir; Vincent Jamonneau; Mamadou Camara; Caroline Clucas; Nono-Raymond K Swar; Dieudonne M Ngoyi; Brice Rotureau; Paul Garside; Alison P Galvani; Bruno Bucheton; Annette MacLeod
Journal:  PLoS Biol       Date:  2019-01-11       Impact factor: 8.029

8.  Structure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase.

Authors:  Marija K Zacharova; Lindsay B Tulloch; Eoin R Gould; Andrew L Fraser; Elizabeth F King; Stefanie K Menzies; Terry K Smith; Gordon J Florence
Journal:  European J Org Chem       Date:  2019-05-29

Review 9.  An Overview of Drug Resistance in Protozoal Diseases.

Authors:  Rita Capela; Rui Moreira; Francisca Lopes
Journal:  Int J Mol Sci       Date:  2019-11-15       Impact factor: 5.923

Review 10.  Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.

Authors:  María Álvarez-Bardón; Yolanda Pérez-Pertejo; César Ordóñez; Daniel Sepúlveda-Crespo; Nestor M Carballeira; Babu L Tekwani; Sankaranarayanan Murugesan; Maria Martinez-Valladares; Carlos García-Estrada; Rosa M Reguera; Rafael Balaña-Fouce
Journal:  Mar Drugs       Date:  2020-03-31       Impact factor: 5.118
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