Sascha Lambrecht1, Laura Sarkisian1, Lotte Saaby1, Tina S Poulsen1, Oke Gerke2, Susanne Hosbond1, Axel C P Diederichsen1, Kristian Thygesen3, Hans Mickley4. 1. Department of Cardiology, Odense University Hospital (OUH), Odense, Denmark. 2. Department of Nuclear Medicine, OUH, Centre of Health Economics Research, University of Southern Denmark, Odense, Denmark. 3. Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. 4. Department of Cardiology, Odense University Hospital (OUH), Odense, Denmark. Electronic address: Hans.Mickley@rsyd.dk.
Abstract
BACKGROUND: Data outlining the mortality and the causes of death in patients with type 1 myocardial infarction, type 2 myocardial infarction, and those with myocardial injury are limited. METHODS: During a 1-year period from January 2010 to January 2011, all hospitalized patients who had cardiac troponin I measured on clinical indication were prospectively studied. Patients with at least one cardiac troponin I value >30 ng/L underwent case ascertainment and individual evaluation by an experienced adjudication committee. Patients were classified as having type 1 myocardial infarction, type 2 myocardial infarction, or myocardial injury according to the criteria of the universal definition of myocardial infarction. Follow-up was ensured until December 31, 2014. Data on mortality and causes of death were obtained from the Danish Civil Registration System and the Danish Register of Causes of Death. RESULTS: Overall, 3762 consecutive patients were followed for a mean of 3.2 years (interquartile range 1.3-3.6 years). All-cause mortality differed significantly among categories: Type 1 myocardial infarction 31.7%, type 2 myocardial infarction 62.2%, myocardial injury 58.7%, and 22.2% in patients with nonelevated troponin values (log-rank test; P < .0001). In patients with type 1 myocardial infarction, 61.3% died from cardiovascular causes, vs 42.6% in patients with type 2 myocardial infarction (P = .015) and 41.2% in those with myocardial injury (P < .0001). The overall mortality and the causes of death did not differ substantially between patients with type 2 myocardial infarction and those with myocardial injury. CONCLUSIONS: Patients with type 2 myocardial infarction and myocardial injury exhibit a significantly higher long-term mortality compared with patients with type 1 myocardial infarction . However, most patients with type 1 myocardial infarction die from cardiovascular causes in contrast to patients with type 2 myocardial infarction and myocardial injury, in whom noncardiovascular causes of death predominate.
BACKGROUND: Data outlining the mortality and the causes of death in patients with type 1 myocardial infarction, type 2 myocardial infarction, and those with myocardial injury are limited. METHODS: During a 1-year period from January 2010 to January 2011, all hospitalized patients who had cardiac troponin I measured on clinical indication were prospectively studied. Patients with at least one cardiac troponin I value >30 ng/L underwent case ascertainment and individual evaluation by an experienced adjudication committee. Patients were classified as having type 1 myocardial infarction, type 2 myocardial infarction, or myocardial injury according to the criteria of the universal definition of myocardial infarction. Follow-up was ensured until December 31, 2014. Data on mortality and causes of death were obtained from the Danish Civil Registration System and the Danish Register of Causes of Death. RESULTS: Overall, 3762 consecutive patients were followed for a mean of 3.2 years (interquartile range 1.3-3.6 years). All-cause mortality differed significantly among categories: Type 1 myocardial infarction 31.7%, type 2 myocardial infarction 62.2%, myocardial injury 58.7%, and 22.2% in patients with nonelevated troponin values (log-rank test; P < .0001). In patients with type 1 myocardial infarction, 61.3% died from cardiovascular causes, vs 42.6% in patients with type 2 myocardial infarction (P = .015) and 41.2% in those with myocardial injury (P < .0001). The overall mortality and the causes of death did not differ substantially between patients with type 2 myocardial infarction and those with myocardial injury. CONCLUSIONS:Patients with type 2 myocardial infarction and myocardial injury exhibit a significantly higher long-term mortality compared with patients with type 1 myocardial infarction . However, most patients with type 1 myocardial infarction die from cardiovascular causes in contrast to patients with type 2 myocardial infarction and myocardial injury, in whom noncardiovascular causes of death predominate.
Authors: Anda Bularga; Caelan Taggart; Filip Mendusic; Dorien M Kimenai; Ryan Wereski; Matthew T H Lowry; Kuan K Lee; Amy V Ferry; Stacey S Stewart; David A McAllister; Anoop S V Shah; Atul Anand; David E Newby; Nicholas L Mills; Andrew R Chapman Journal: JAMA Netw Open Date: 2022-07-01
Authors: Ryan Wereski; Dorien M Kimenai; Anda Bularga; Caelan Taggart; David J Lowe; Nicholas L Mills; Andrew R Chapman Journal: Eur Heart J Date: 2022-01-13 Impact factor: 35.855
Authors: Hanumantha R Jogu; Sameer Arora; Muthiah Vaduganathan; Arman Qamar; Ambarish Pandey; Parag A Chevli; Tusharkumar H Pansuriya; Muhammad I Ahmad; Abhishek Dutta; Padageshwar R Sunkara; Waqas Qureshi; Sujethra Vasu; Bharathi Upadhya; Deepak L Bhatt; James L Januzzi; David Herrington Journal: Clin Cardiol Date: 2019-04-12 Impact factor: 2.882
Authors: Harvey D White; Ph Gabriel Steg; Michael Szarek; Deepak L Bhatt; Vera A Bittner; Rafael Diaz; Jay M Edelberg; Andrejs Erglis; Shaun G Goodman; Corinne Hanotin; Robert A Harrington; J Wouter Jukema; Renato D Lopes; Kenneth W Mahaffey; Angele Moryusef; Robert Pordy; Matthew T Roe; Piyamitr Sritara; Pierluigi Tricoci; Andreas M Zeiher; Gregory G Schwartz Journal: Eur Heart J Date: 2019-09-01 Impact factor: 29.983
Authors: Andrew P DeFilippis; Andrew R Chapman; Nicholas L Mills; James A de Lemos; Armin Arbab-Zadeh; L Kristin Newby; David A Morrow Journal: Circulation Date: 2019-08-16 Impact factor: 29.690
Authors: Christopher Reid; Ahmed Alturki; Andrew Yan; Derek So; Dennis Ko; Jean-Francois Tanguay; Amal Bessissow; Shamir Mehta; Shaun Goodman; Thao Huynh Journal: CJC Open Date: 2020-02-24