| Literature DB >> 29274489 |
Rinat F Salikov1, Konstantin P Trainov1, Irina K Belousova2, Aleksandr Yu Belyy1, Ulyana Sh Fatkullina3, Regina V Mulyukova3, Liana F Zainullina4, Yulia V Vakhitova4, Yury V Tomilov5.
Abstract
The influence of a series of tryptamine derivatives on the viability of normal (HEK293) and tumor (HepG2, Jurkat and SH-SY5Y) cells has been evaluated. All tryptamines tested were three different substitution types: C- and N-branching, and indole benzylation. All the derivations enhance the activity of compounds separately, although the effects of different substitutions were not additive. Thus, combinations of C- and N-branchings as well as C-branching and indole benzylation gave little or no increase in activity.Entities:
Keywords: Branching amines; Cyclopropylketone arylhydrazones; Cytotoxicity; MAO degradation; Rearrangement; Tryptamine derivatives
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Year: 2017 PMID： 29274489 DOI： 10.1016/j.ejmech.2017.12.028
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514