| Literature DB >> 29274427 |
Shangshang Li1, Min Liu1, Chen Zhang1, Chengye Tian2, Xiuxiu Wang1, Xinling Song1, Huijuan Jing1, Zheng Gao1, Zhenzhen Ren1, Weiru Liu3, Jianjun Zhang4, Le Jia5.
Abstract
In present study, the soluble polysaccharides by enzyme-assisted extraction from Agaricus bisporus (EnAPS) and its purified fractions of EnAPS-1, -2 and -3 were successfully obtained, and the antioxidant activities and anti-aging effects were investigated. The in vitro antioxidant assay demonstrated that EnAPS-2 had superior scavenging activities on DPPH and hydroxyl radicals, chelating activities of Fe2+ and reducing power. The in vivo animal experiments showed that both EnAPS and its purifies fractions had potential anti-aging effects against the d-galctose-induced aging diseases on liver, kidney, brain and skin, possibly by increasing the antioxidant enzymes, reducing the lipid peroxidation, improving the organ functions and remitting the lipid metabolism. The conclusions demonstrated that the polysaccharides by A. bisporus might be suitable for applying functional foods and natural drugs in preventing and delaying the aging and its complications.Entities:
Keywords: Agaricus bisporus; Anti-aging activities; Antioxidant activities; Enzyme-assisted extraction; Polysaccharides; Purification
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Year: 2017 PMID： 29274427 DOI： 10.1016/j.ijbiomac.2017.12.108
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953