Literature DB >> 2927401

Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.

U Andersson1, J E Häggström, E D Levin, U Bondesson, M Valverius, L M Gunne.   

Abstract

Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.

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Year:  1989        PMID： 2927401     DOI： 10.1002/mds.870040107

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  3 in total

Review 1.  Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia.

Authors:  J L Waddington
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

Review 2.  Antipsychotic-Induced movement disorders in the elderly: epidemiology and treatment recommendations.

Authors:  M R Caligiuri; D V Jeste; J P Lacro
Journal:  Drugs Aging       Date:  2000-11       Impact factor: 3.923

3.  Striatal binding of 11C-NMSP studied with positron emission tomography in patients with persistent tardive dyskinesia: no evidence for altered dopamine D2 receptor binding.

Authors:  U Andersson; S A Eckernäs; P Hartvig; J Ulin; B Långström; J E Häggström
Journal:  J Neural Transm Gen Sect       Date:  1990
  3 in total

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