N A Malini1, K Roy George2. 1. Research Scholar, Post Graduate & Research Dept. of Zoology, St. Thomas College Kozhencherry-689641, Kerala, India. Electronic address: namalini@gmail.com. 2. Head, Assistant Professor & Research Guide, Post Graduate & Research Dept. of Zoology, St. Thomas College Kozhencherry-689641, Kerala, India. Electronic address: dr.roygeorgek@gmail.com.
Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder among reproductive aged women, leading to infertility. One of the common clinical manifestations in PCOS is that there is a difference in the range of LH production in different case of PCOS and accordingly variability in LH:FSH ratio was observed. OBJECTIVE: The aim of the present study was to evaluate different ranges of LH:FSH ratios in PCOS. EXPERIMENTAL DESIGN: In this cross sectional study, a consecutive series of 745 women (aged 28.11 ± 0.2) who were subjected to infertility treatment at specialist infertility clinics in central Travancore region were considered. About 50 healthy females (aged 27.58 ± 0.4) with regular menstrual cycles were regarded as control. The data were collected from hospital records using subject's written informed consent. RESULTS: PCOS patients were observed to have different ranges of LH:FSH ratios from < 1 range to 4.6-5.5 and subjects were classified into 7 PCO subgroups on the basis of their LH:FSH ratios. In whole PCO group, body weight, LH, FSH, LH:FSH ratio, insulin, HbA1c, estradiol, testosterone and TSH were significantly (P < .05) increased whereas progesterone and SHBG levels were significantly (P < .05) decreased in comparison to control. In various PCO subgroups as LH levels and LH:FSH ratios were increased, levels of insulin, testosterone and AMH were increased and SHBG levels were decreased accordingly. CONCLUSION: This finding suggested a dependence of insulin, LH and testosterone in initiating the hormonal imbalances in PCOS.
BACKGROUND:Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder among reproductive aged women, leading to infertility. One of the common clinical manifestations in PCOS is that there is a difference in the range of LH production in different case of PCOS and accordingly variability in LH:FSH ratio was observed. OBJECTIVE: The aim of the present study was to evaluate different ranges of LH:FSH ratios in PCOS. EXPERIMENTAL DESIGN: In this cross sectional study, a consecutive series of 745 women (aged 28.11 ± 0.2) who were subjected to infertility treatment at specialist infertility clinics in central Travancore region were considered. About 50 healthy females (aged 27.58 ± 0.4) with regular menstrual cycles were regarded as control. The data were collected from hospital records using subject's written informed consent. RESULTS:PCOSpatients were observed to have different ranges of LH:FSH ratios from < 1 range to 4.6-5.5 and subjects were classified into 7 PCO subgroups on the basis of their LH:FSH ratios. In whole PCO group, body weight, LH, FSH, LH:FSH ratio, insulin, HbA1c, estradiol, testosterone and TSH were significantly (P < .05) increased whereas progesterone and SHBG levels were significantly (P < .05) decreased in comparison to control. In various PCO subgroups as LH levels and LH:FSH ratios were increased, levels of insulin, testosterone and AMH were increased and SHBG levels were decreased accordingly. CONCLUSION: This finding suggested a dependence of insulin, LH and testosterone in initiating the hormonal imbalances in PCOS.
Authors: Maha H Daghestani; Mazin H Daghestani; Mamoon Daghistani; Khushboo Ambreen; Fadwa S Albalawi; Lina M AlNeghery; Arjumand S Warsy Journal: BMC Endocr Disord Date: 2020-05-07 Impact factor: 2.763
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