Literature DB >> 29273273

Utility of DNA methylation to assess placental health.

Samantha L Wilson1, Wendy P Robinson2.   

Abstract

DNA methylation (DNAm), a mitotically stable epigenetic mark, can influence as well as reflect gene expression. DNAm has been gaining interest for use as a biomarker for many conditions including placental insufficiency, specifically preeclampsia (PE) and intrauterine growth restriction (IUGR). Additionally, DNAm may retain a "memory" of earlier in utero exposures and hence provide insight into pathogeneses occurring earlier in gestation. This review will discuss the placental DNA methylome, the uses of DNAm to assess placental health, and considerations and limitations to understand in epigenome-wide association studies (EWAS).
Copyright © 2017 IFPA, Elsevier Ltd. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  Cell type composition; DNA methylation; Epigenetic wide association studies; Intrauterine growth restriction; Placental insufficiency; Preeclampsia; Reproducibility

Mesh：

Year:  2017        PMID： 29273273     DOI： 10.1016/j.placenta.2017.12.013

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  5 in total

Review 1.  Hemochorial placentation: development, function, and adaptations.

Authors:  Michael J Soares; Kaela M Varberg; Khursheed Iqbal
Journal:  Biol Reprod       Date:  2018-07-01       Impact factor: 4.285

Review 2.  Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer.

Authors:  Philip J Lupo; Lauren M Petrick; Thanh T Hoang; Amanda E Janitz; Erin L Marcotte; Jeremy M Schraw; Manish Arora; Michael E Scheurer
Journal:  Bioessays       Date:  2021-06-09       Impact factor: 4.653

3.  Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia.

Authors:  Katherine Leavey; Samantha L Wilson; Shannon A Bainbridge; Wendy P Robinson; Brian J Cox
Journal:  Clin Epigenetics       Date:  2018-03-02       Impact factor: 6.551

4.  Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta.

Authors:  Perrine Nogues; Esther Dos Santos; Hélène Jammes; Paul Berveiller; Lucie Arnould; François Vialard; Marie-Noëlle Dieudonné
Journal:  Clin Epigenetics       Date:  2019-02-07       Impact factor: 6.551

5.  Embryonic Arsenic Exposure Triggers Long-Term Behavioral Impairment with Metabolite Alterations in Zebrafish.

Authors:  Noraini Abu Bakar; Wan Norhamidah Wan Ibrahim; Che Azurahanim Che Abdullah; Nurul Farhana Ramlan; Khozirah Shaari; Shamarina Shohaimi; Ahmed Mediani; Nurrul Shaqinah Nasruddin; Cheol-Hee Kim; Siti Munirah Mohd Faudzi
Journal:  Toxics       Date:  2022-08-24
  5 in total

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