Hideo Takahashi1, Bora Kahramangil2, Eren Berber3. 1. Department of General Surgery, Cleveland Clinic Foundation, Cleveland, OH. 2. Department of Endocrine Surgery, Cleveland Clinic Foundation, Cleveland, OH. 3. Department of General Surgery, Cleveland Clinic Foundation, Cleveland, OH; Department of Endocrine Surgery, Cleveland Clinic Foundation, Cleveland, OH. Electronic address: berbere@ccf.org.
Abstract
BACKGROUND: Microwave thermosphere ablation is a new treatment modality that creates spherical ablation zones using a single antenna. This study aims to analyze local recurrence associated with this new treatment modality in patients with malignant liver tumors. METHODS: This is a prospective clinical study of patients who underwent microwave thermosphere ablation of malignant liver tumors between September 2014 and March 2017. Clinical, operative, and oncologic parameters were analyzed using Kaplan-Meier survival and Cox proportional hazards model. RESULTS: One hundred patients underwent 301 ablations. Ablations were performed laparoscopically in 87 and open in 13 patients. Pathology included neuroendocrine liver metastasis (n = 115), colorectal liver metastasis (n = 100), hepatocellular cancer (n = 21), and other tumor types (n = 65). Ninety-day morbidity was 7% with one not procedure-related mortality. Median follow-up was 16 months with 65% of patients completing at least 12 months of follow-up. The rate of local tumor recurrence rate per lesion was 6.6% (20/301). Local tumor, new hepatic, and extrahepatic recurrences were detected in 15%, 40%, and 40% of patients, respectively. Local recurrence rate per pathology was 12% for both colorectal liver metastasis (12/100) and other metastatic tumors (8/65). No local recurrence was observed to date in the neuroendocrine liver metastasis and in the limited number of patients with hepatocellular cancers. Tumor size >3 cm and tumor type were independent predictors of local recurrence. CONCLUSION: This is the first study to analyze local recurrence after microwave thermosphere ablation of malignant liver tumors. Short-term local tumor control rate compares favorably with that reported for radiofrequency and other microwave technologies in the literature.
BACKGROUND: Microwave thermosphere ablation is a new treatment modality that creates spherical ablation zones using a single antenna. This study aims to analyze local recurrence associated with this new treatment modality in patients with malignant liver tumors. METHODS: This is a prospective clinical study of patients who underwent microwave thermosphere ablation of malignant liver tumors between September 2014 and March 2017. Clinical, operative, and oncologic parameters were analyzed using Kaplan-Meier survival and Cox proportional hazards model. RESULTS: One hundred patients underwent 301 ablations. Ablations were performed laparoscopically in 87 and open in 13 patients. Pathology included neuroendocrine liver metastasis (n = 115), colorectal liver metastasis (n = 100), hepatocellular cancer (n = 21), and other tumor types (n = 65). Ninety-day morbidity was 7% with one not procedure-related mortality. Median follow-up was 16 months with 65% of patients completing at least 12 months of follow-up. The rate of local tumor recurrence rate per lesion was 6.6% (20/301). Local tumor, new hepatic, and extrahepatic recurrences were detected in 15%, 40%, and 40% of patients, respectively. Local recurrence rate per pathology was 12% for both colorectal liver metastasis (12/100) and other metastatic tumors (8/65). No local recurrence was observed to date in the neuroendocrine liver metastasis and in the limited number of patients with hepatocellular cancers. Tumor size >3 cm and tumor type were independent predictors of local recurrence. CONCLUSION: This is the first study to analyze local recurrence after microwave thermosphere ablation of malignant liver tumors. Short-term local tumor control rate compares favorably with that reported for radiofrequency and other microwave technologies in the literature.
Authors: I F Vilkovyskiy; Yu A Vatnikov; E V Kulikov; E D Sotnikova; S A Yagnikov; S B Seleznev; E A Krotova; V M Byakhova; V N Grishin; V P Avdotin Journal: Vet World Date: 2020-03-04
Authors: Francesco De Cobelli; Marco Calandri; Angelo Della Corte; Roberta Sirovich; Carlo Gazzera; Paolo Della Vigna; Guido Bonomo; Gianluca Maria Varano; Daniele Maiettini; Giovanni Mauri; Nicola Camisassi; Stephanie Steidler; Francesca Ratti; Simone Gusmini; Monica Ronzoni; Luca Aldrighetti; Bruno C Odisio; Patrizia Racca; Paolo Fonio; Andrea Veltri; Franco Orsi Journal: Eur Radiol Date: 2022-01-29 Impact factor: 7.034