| Literature DB >> 29273110 |
Kunal Malik1, Emma Guttman-Yassky2.
Abstract
Alopecia areata is a T-cell-mediated disease that shares phenotypic similarities with other inflammatory diseases, particularly atopic dermatitis, and lacks safe, effective, mechanism-specific treatments. Increasing data suggests that alopecia areata harbors contributions of T helper type 1, T helper type 2, T helper type 17/IL-23, and phosphodiesterase pathways. Antagonism of these axes is undergoing evaluation, and might elucidate the underlying molecular circuitry of alopecia areata, advancing the translational revolution for this disease.Entities:
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Year: 2018 PMID： 29273110 DOI： 10.1016/j.jisp.2017.10.005
Source DB: PubMed Journal: J Investig Dermatol Symp Proc ISSN： 1087-0024