Ursula S Schwab1,2, Maria A Lankinen1, Vanessa D de Mello1, Suvi M Manninen1, Sudhir Kurl1, Kari J Pulkki3,4, David E Laaksonen2,5, Arja T Erkkilä1. 1. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. 2. Internal Medicine, Institute of Clinical Medicine, Kuopio University Hospital, Kuopio, Finland. 3. Clinical Chemistry, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. 4. Eastern Finland Laboratory Centre (ISLAB), Kuopio, Finland. 5. Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Abstract
SCOPE: The aim of the study is to examine whether lean fish (LF), fatty fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with impaired glucose metabolism. METHODS AND RESULTS: Altogether 79 volunteers with impaired fasting glucose, BMI 25-36 kg m-2 , age 43-72 years, participated in a 12-week randomized controlled trial with four parallel groups, that is, the FF (four fish meals/week), LF (four fish meals/week), CSO (10 g d-1 ALA), and control (limited intakes of fish and sources of ALA) groups. The proportions of eicosapentaenoic acid and DHA increase in plasma lipids in the FF group, and the proportion of ALA increase in the CSO group (p < 0.0001 for all). In the CSO group, total and LDL-cholesterol (C) concentrations decrease compared with the FF and LF groups; LDL-C/HDL-C and ApoB/ApoA-I ratios decrease compared with the LF group. There are no significant changes in glucose metabolism or markers of low-grade inflammation. CONCLUSIONS: A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.
RCT Entities:
SCOPE: The aim of the study is to examine whether lean fish (LF), fatty fish (FF), and camelina sativa oil (CSO), a plant-based source of alpha-linolenic acid (ALA), differ in their metabolic effects in subjects with impaired glucose metabolism. METHODS AND RESULTS: Altogether 79 volunteers with impaired fasting glucose, BMI 25-36 kg m-2 , age 43-72 years, participated in a 12-week randomized controlled trial with four parallel groups, that is, the FF (four fish meals/week), LF (four fish meals/week), CSO (10 g d-1 ALA), and control (limited intakes of fish and sources of ALA) groups. The proportions of eicosapentaenoic acid and DHA increase in plasma lipids in the FF group, and the proportion of ALA increase in the CSO group (p < 0.0001 for all). In the CSO group, total and LDL-cholesterol (C) concentrations decrease compared with the FF and LF groups; LDL-C/HDL-C and ApoB/ApoA-I ratios decrease compared with the LF group. There are no significant changes in glucose metabolism or markers of low-grade inflammation. CONCLUSIONS: A diet enriched in CSO improves serum lipid profile as compared with a diet enriched in FF or LF in subjects with impaired fasting glucose, with no differences in glucose metabolism or concentrations of inflammatory markers.
Authors: Sara K Hotton; Meridith Kammerzell; Ron Chan; Bryan T Hernandez; Hugh A Young; Christian Tobias; Thomas McKeon; Jenny Brichta; Nathan J Thomson; James G Thomson Journal: Plants (Basel) Date: 2020-05-19
Authors: Vanessa D de Mello; Ingrid Dahlman; Maria Lankinen; Sudhir Kurl; Leena Pitkänen; David E Laaksonen; Ursula S Schwab; Arja T Erkkilä Journal: Nutr Diabetes Date: 2019-01-09 Impact factor: 5.097