| Literature DB >> 29271645 |
Li Liu1,2, Li Bao1,2, Long Wang1, Ke Ma1,2, Junjie Han1,2, Yanlong Yang1, Ruixing Liu1,2, Jinwei Ren1, Wenbing Yin1,2, Wenzhao Wang1, Hongwei Liu1,2.
Abstract
As part of our program to discover new bioactive agents from fungi, 13 new alkaloids accompanying 13 known related alkaloids were isolated from a wild strain of Aspergillus oryzae L1020. Compounds 1 and 2 have unprecedented 6/6/5/7/5 and 6/6/6/5/5 chemical skeletons, representing new members of quinoline alkaloids. Compound 3 is a new macrolactam with an unusual 6/5/6/8 ring system. Compounds 4-13 are new α-cyclopiazonic acid-related alkaloids. The absolute configurations of 1-4, 8, and 9 were assigned by electronic circular dichroism calculations. Compounds 2, 5, 6, 11, 14, 22, and 26 exhibit pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 25-100 μM.Entities:
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Year: 2018 PMID： 29271645 DOI： 10.1021/acs.joc.7b02802
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354