Charles A Riley1, Eric L Wu1, Mei-Chin Hsieh2, Michael J Marino1, Xiao-Cheng Wu2, Edward D McCoul1,3,4. 1. Department of Otolaryngology-Head and Neck Surgery, Tulane University School of Medicine, New Orleans, Louisiana. 2. Louisiana Tumor Registry, School of Public Health, Louisiana State University Health Sciences Center, New Orleans. 3. Department of Otorhinolaryngology, Ochsner Clinic Foundation, New Orleans, Louisiana. 4. Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, Louisiana.
Abstract
Importance: Chronic inflammatory states have been linked to the development of malignancy. Gastroesophageal reflux disease (GERD) is a known risk factor for esophageal adenocarcinoma as the end result of chronic inflammatory changes. Objective: To investigate the association of GERD with the risk of malignancy in the upper aerodigestive tract (UADT). Design, Setting, and Participants: We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare database to conduct a case-control study of individuals in the United States who had been added from January 2003 through December 2011 and were 66 years or older. The study included patients diagnosed with malignancy of the larynx, hypopharynx, oropharynx, tonsil, nasopharynx, and paranasal sinuses. GERD was examined as an exposure. Controls were matched from a 5% random sample of Medicare beneficiaries without cancer. Multivariable unconditional logistic regression was performed. Main Outcomes and Measures: Incidence of invasive malignancies of the UADT. Results: A total of 13 805 patients (median [range] age, 74 [66-99] years; 3418 women [24.76%] and 10 387 men [75.24%]) with malignancy of the UADT were compared with 13 805 patients without disease and were matched for sex, age group, and year of diagnosis. GERD was associated with a greater odds of developing malignancy of the larynx (adjusted odds ratio [aOR], 2.86; 95% CI, 2.65-3.09), hypopharynx (aOR, 2.54; 95% CI 1.97-3.29), oropharynx (aOR, 2.47; 95% CI, 1.90-3.23), tonsil (aOR, 2.14; 95% CI, 1.82-2.53), nasopharynx (aOR, 2.04; 95% CI, 1.56-2.66), and paranasal sinuses (aOR, 1.40; 95% CI, 1.15-1.70). Conclusions and Relevance: GERD is associated with the presence of malignancy of the UADT in the US elderly population. This epidemiological association requires further examination to determine causality and diagnostic utility.
Importance: Chronic inflammatory states have been linked to the development of malignancy. Gastroesophageal reflux disease (GERD) is a known risk factor for esophageal adenocarcinoma as the end result of chronic inflammatory changes. Objective: To investigate the association of GERD with the risk of malignancy in the upper aerodigestive tract (UADT). Design, Setting, and Participants: We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare database to conduct a case-control study of individuals in the United States who had been added from January 2003 through December 2011 and were 66 years or older. The study included patients diagnosed with malignancy of the larynx, hypopharynx, oropharynx, tonsil, nasopharynx, and paranasal sinuses. GERD was examined as an exposure. Controls were matched from a 5% random sample of Medicare beneficiaries without cancer. Multivariable unconditional logistic regression was performed. Main Outcomes and Measures: Incidence of invasive malignancies of the UADT. Results: A total of 13 805 patients (median [range] age, 74 [66-99] years; 3418 women [24.76%] and 10 387 men [75.24%]) with malignancy of the UADT were compared with 13 805 patients without disease and were matched for sex, age group, and year of diagnosis. GERD was associated with a greater odds of developing malignancy of the larynx (adjusted odds ratio [aOR], 2.86; 95% CI, 2.65-3.09), hypopharynx (aOR, 2.54; 95% CI 1.97-3.29), oropharynx (aOR, 2.47; 95% CI, 1.90-3.23), tonsil (aOR, 2.14; 95% CI, 1.82-2.53), nasopharynx (aOR, 2.04; 95% CI, 1.56-2.66), and paranasal sinuses (aOR, 1.40; 95% CI, 1.15-1.70). Conclusions and Relevance: GERD is associated with the presence of malignancy of the UADT in the US elderly population. This epidemiological association requires further examination to determine causality and diagnostic utility.
Authors: John A Evans; Dayna S Early; Norio Fukami; Tamir Ben-Menachem; Vinay Chandrasekhara; Krishnavel V Chathadi; G Anton Decker; Robert D Fanelli; Deborah A Fisher; Kimberly Q Foley; Joo Ha Hwang; Rajeev Jain; Terry L Jue; Khalid M Khan; Jenifer Lightdale; Phyllis M Malpas; John T Maple; Shabana F Pasha; John R Saltzman; Ravi N Sharaf; Amandeep Shergill; Jason A Dominitz; Brooks D Cash Journal: Gastrointest Endosc Date: 2012-12 Impact factor: 9.427
Authors: Shao-Ming Wang; Neal D Freedman; Hormuzd A Katki; Charles Matthews; Barry I Graubard; Lisa L Kahle; Christian C Abnet Journal: Cancer Date: 2021-02-22 Impact factor: 6.921