Literature DB >> 29270417

Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells.

Kristen J Brennand1.   

Abstract

Entities:  

Year:  2017        PMID： 29270417      PMCID： PMC5723749          DOI： 10.21037/sci.2017.10.05

Source DB:  PubMed          Journal:  Stem Cell Investig        ISSN： 2306-9759


× No keyword cloud information.
  33 in total

1.  Modelling schizophrenia using human induced pluripotent stem cells.

Authors:  Kristen J Brennand; Anthony Simone; Jessica Jou; Chelsea Gelboin-Burkhart; Ngoc Tran; Sarah Sangar; Yan Li; Yangling Mu; Gong Chen; Diana Yu; Shane McCarthy; Jonathan Sebat; Fred H Gage
Journal:  Nature       Date:  2011-04-13       Impact factor: 49.962

2.  Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells.

Authors:  Alessandro Prigione; James Adjaye
Journal:  Int J Dev Biol       Date:  2010       Impact factor: 2.203

3.  The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.

Authors:  Alessandro Prigione; Beatrix Fauler; Rudi Lurz; Hans Lehrach; James Adjaye
Journal:  Stem Cells       Date:  2010-04       Impact factor: 6.277

4.  LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

Authors:  Ha Nam Nguyen; Blake Byers; Branden Cord; Aleksandr Shcheglovitov; James Byrne; Prachi Gujar; Kehkooi Kee; Birgitt Schüle; Ricardo E Dolmetsch; William Langston; Theo D Palmer; Renee Reijo Pera
Journal:  Cell Stem Cell       Date:  2011-03-04       Impact factor: 24.633

5.  Modeling human cortical development in vitro using induced pluripotent stem cells.

Authors:  Jessica Mariani; Maria Vittoria Simonini; Dean Palejev; Livia Tomasini; Gianfilippo Coppola; Anna M Szekely; Tamas L Horvath; Flora M Vaccarino
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-03       Impact factor: 11.205

6.  Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.

Authors:  Mahru C An; Ningzhe Zhang; Gary Scott; Daniel Montoro; Tobias Wittkop; Sean Mooney; Simon Melov; Lisa M Ellerby
Journal:  Cell Stem Cell       Date:  2012-06-28       Impact factor: 24.633

7.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

8.  A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors.

Authors:  Wen-Ning Zhao; Chialin Cheng; Kraig M Theriault; Steven D Sheridan; Li-Huei Tsai; Stephen J Haggarty
Journal:  J Biomol Screen       Date:  2012-08-24

9.  Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells.

Authors:  Donna McLaren; Thorsten Gorba; Anita Marguerie de Rotrou; Gopalan Pillai; Clare Chappell; Alison Stacey; Sarah Lingard; Anna Falk; Austin Smith; Philipp Koch; Oliver Brüstle; Richard Vickers; Jon Tinsley; David Flanders; Paul Bello; Stewart Craig
Journal:  J Biomol Screen       Date:  2012-10-04

10.  Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.

Authors:  Dhruv Sareen; Allison D Ebert; Brittany M Heins; Jered V McGivern; Loren Ornelas; Clive N Svendsen
Journal:  PLoS One       Date:  2012-06-19       Impact factor: 3.240
View more
  2 in total

Review 1.  Modeling the complex genetic architectures of brain disease.

Authors:  Michael B Fernando; Tim Ahfeldt; Kristen J Brennand
Journal:  Nat Genet       Date:  2020-03-23       Impact factor: 38.330

2.  Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis.

Authors:  Gemma Gomez-Giro; Jonathan Arias-Fuenzalida; Javier Jarazo; Dagmar Zeuschner; Muhammad Ali; Nina Possemis; Silvia Bolognin; Rashi Halder; Christian Jäger; Willemijn F E Kuper; Peter M van Hasselt; Holm Zaehres; Antonio Del Sol; Herman van der Putten; Hans R Schöler; Jens C Schwamborn
Journal:  Acta Neuropathol Commun       Date:  2019-12-30       Impact factor: 7.801
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.