Literature DB >> 29269951

Mechanoreciprocity in cell migration.

Sjoerd van Helvert1, Cornelis Storm2, Peter Friedl3,4,5.   

Abstract

Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.

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Year:  2017        PMID: 29269951      PMCID: PMC5943039          DOI: 10.1038/s41556-017-0012-0

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN: 1465-7392            Impact factor:   28.824


  170 in total

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Journal:  Nat Cell Biol       Date:  2015-06-29       Impact factor: 28.824

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  136 in total

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Review 6.  "Looping In" Mechanics: Mechanobiologic Regulation of the Nucleus and the Epigenome.

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Review 8.  Balancing forces in migration.

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Review 9.  Defining the Hallmarks of Metastasis.

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10.  Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.

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