Literature DB >> 29269364

Deliberate self-poisoning with long-acting anticoagulant rodenticides.

Danielle Reimer1, Melissa Smith1, Sayed Ali2.   

Abstract

Long-acting anticoagulant rodenticides, also called superwarfarins, are known for their greater potency, longer half-life and delayed onset of symptoms. Cases of superwarfarin poisoning can pose a diagnostic and clinical challenge due to a wide array of presentations and prolonged severe coagulopathy requiring months of high-dose oral vitamin K therapy. The most common presentation of long-acting anticoagulant rodenticide poisoning is mucocutaneous bleeding, with other common presentations including haematuria, gingival bleeding, epistaxis and gastrointestinal bleeding. We discuss a case of deliberate self-poisoning with long-acting anticoagulant rodenticides presenting with haematuria and coagulation values above measurable limits. This case is important as it required immediate and maintenance therapy in order to prevent profound bleeding, as well as the evaluation of the patient's psychosocial factors to ensure medical compliance and to prevent refractory complications or repeated self-harm. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  haematology (drugs and medicines); medical management; poisoning

Mesh:

Substances:

Year:  2017        PMID: 29269364      PMCID: PMC5743880          DOI: 10.1136/bcr-2017-222170

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  9 in total

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Review 2.  Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence.

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Review 3.  The global burden of fatal self-poisoning with pesticides 2006-15: Systematic review.

Authors:  Emma J Mew; Prianka Padmanathan; Flemming Konradsen; Michael Eddleston; Shu-Sen Chang; Michael R Phillips; David Gunnell
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Journal:  Clin Toxicol (Phila)       Date:  2011-06       Impact factor: 4.467

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Authors:  Ashwini Nadkarni; Mark A Oldham; Mark Howard; Isidore Berenbaum
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Review 7.  Long-Acting Anticoagulant Rodenticide (Superwarfarin) Poisoning: A Review of Its Historical Development, Epidemiology, and Clinical Management.

Authors:  Nathan King; Minh-Ha Tran
Journal:  Transfus Med Rev       Date:  2015-07-06

Review 8.  Psychosocial interventions following self-harm in adults: a systematic review and meta-analysis.

Authors:  Keith Hawton; Katrina G Witt; Tatiana L Taylor Salisbury; Ella Arensman; David Gunnell; Philip Hazell; Ellen Townsend; Kees van Heeringen
Journal:  Lancet Psychiatry       Date:  2016-07-13       Impact factor: 27.083

9.  Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period.

Authors:  Jianhai Long; Xiaobo Peng; Yuan Luo; Yawei Sun; Guodong Lin; Yongan Wang; Zewu Qiu
Journal:  Medicine (Baltimore)       Date:  2016-12       Impact factor: 1.889

  9 in total

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