BACKGROUND: Red blood cell (RBC) transfusion is a well-known predictor of acute kidney injury (AKI) and death after cardiac surgery. This study aimed to define the relationship between age and the need for RBC. METHODS: Study population included 1,765 consecutive patients undergoing on-pump procedures from 2013 to 2015. The relationship between RBC transfusion and both survival and AKI, and any interaction with age was estimated. A propensity score for the likelihood to receive RBC transfusion was calculated using multivariate logistic regression analysis to adjust for the effect of confounding factors. A logistic estimation curve was developed to investigate the interaction between this score and age. RESULTS: Patients receiving RBC transfusions had more comorbidities irrespective of age. Elderly patients underwent transfusion more often than younger patients with a 1.3-fold increase in the relative risk for transfusion. Age did not independently predict the need for RBC. AKI and mortality rates were significantly higher in transfused subsets irrespective of age. CONCLUSIONS: Comorbidity profile and not age per se confers an increased risk of transfusion.
BACKGROUND: Red blood cell (RBC) transfusion is a well-known predictor of acute kidney injury (AKI) and death after cardiac surgery. This study aimed to define the relationship between age and the need for RBC. METHODS: Study population included 1,765 consecutive patients undergoing on-pump procedures from 2013 to 2015. The relationship between RBC transfusion and both survival and AKI, and any interaction with age was estimated. A propensity score for the likelihood to receive RBC transfusion was calculated using multivariate logistic regression analysis to adjust for the effect of confounding factors. A logistic estimation curve was developed to investigate the interaction between this score and age. RESULTS: Patients receiving RBC transfusions had more comorbidities irrespective of age. Elderly patients underwent transfusion more often than younger patients with a 1.3-fold increase in the relative risk for transfusion. Age did not independently predict the need for RBC. AKI and mortality rates were significantly higher in transfused subsets irrespective of age. CONCLUSIONS: Comorbidity profile and not age per se confers an increased risk of transfusion.
Authors: Radoslaw Litwinowicz; Krzysztof Bartus; Rafal Drwila; Boguslaw Kapelak; Janusz Konstanty-Kalandyk; Robert Sobczynski; Karol Wierzbicki; Magdalena Bartuś; Anna Chrapusta; Tomasz Timek; Stanislaw Bartus; Krzysztof Oles; Jerzy Sadowski Journal: J Cardiothorac Vasc Anesth Date: 2015-01-16 Impact factor: 2.628
Authors: Victor A Ferraris; Jeremiah R Brown; George J Despotis; John W Hammon; T Brett Reece; Sibu P Saha; Howard K Song; Ellen R Clough; Linda J Shore-Lesserson; Lawrence T Goodnough; C David Mazer; Aryeh Shander; Mark Stafford-Smith; Jonathan Waters; Robert A Baker; Timothy A Dickinson; Daniel J FitzGerald; Donald S Likosky; Kenneth G Shann Journal: Ann Thorac Surg Date: 2011-03 Impact factor: 4.330
Authors: Rutger-Jan Nuis; Josep Rodés-Cabau; Jan-Malte Sinning; Leen van Garsse; Joelle Kefer; Johan Bosmans; Antonio E Dager; Nicolas van Mieghem; Marina Urena; Georg Nickenig; Nikos Werner; Jos Maessen; Parla Astarci; Sergio Perez; Luis M Benitez; Eric Dumont; Ron T van Domburg; Peter P de Jaegere Journal: Circ Cardiovasc Interv Date: 2012-10-09 Impact factor: 6.546
Authors: Keyvan Karkouti; Duminda N Wijeysundera; Terrence M Yau; Stuart A McCluskey; Christopher T Chan; Pui-Yuen Wong; W Scott Beattie Journal: Anesthesiology Date: 2011-09 Impact factor: 7.892
Authors: Rutger-Jan Nuis; Jan-Malte Sinning; Josep Rodés-Cabau; Michael Gotzmann; Leen van Garsse; Joelle Kefer; Johan Bosmans; Gerald Yong; Antonio E Dager; Ana Revilla-Orodea; Marina Urena; Georg Nickenig; Nikos Werner; Jos Maessen; Parla Astarci; Sergio Perez; Luis M Benitez; Ignacio J Amat-Santos; Javier López; Eric Dumont; Nicolas van Mieghem; Teun van Gelder; Ron T van Domburg; Peter P de Jaegere Journal: Circ Cardiovasc Interv Date: 2013-11-26 Impact factor: 6.546