| Literature DB >> 29265147 |
Marcel I Ramirez1, Maria G Amorim2, Catarina Gadelha3, Ivana Milic4, Joshua A Welsh5, Vanessa M Freitas6, Muhammad Nawaz7, Naveed Akbar8, Yvonne Couch9, Laura Makin10, Fiona Cooke11, Andre L Vettore12, Patricia X Batista12, Roberta Freezor13, Julia A Pezuk14, Lívia Rosa-Fernandes15, Ana Claudia O Carreira6, Andrew Devitt4, Laura Jacobs16, Israel T Silva2, Gillian Coakley17, Diana N Nunes2, Dave Carter18, Giuseppe Palmisano19, Emmanuel Dias-Neto20.
Abstract
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nanosized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review.Entities:
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Year: 2018 PMID： 29265147 DOI： 10.1039/c7nr08360b
Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790