Neomi Vin-Raviv1,2, T F Akinyemiju3, S Galea4, D H Bovbjerg5. 1. School of Social Work, College of Health and Human Sciences, Colorado State University, Fort Collins, CO, USA. Neomi.Vin-Raviv@colostate.edu. 2. University of Northern Colorado Cancer Rehabilitation Institute, School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO, USA. Neomi.Vin-Raviv@colostate.edu. 3. Department of Epidemiology, University of Alabama School of Public Health, Birmingham, AL, USA. 4. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. 5. University of Pittsburgh, and the UPMC-Hillman Cancer Center, Division Departments of Psychiatry, Psychology, Behavioral & Community Health Sciences, and Health & Community Systems, Pittsburgh, PA, USA.
Abstract
PURPOSE: Sleep disturbances are recognized as a problem for many cancer patients, but little is known about the prevalence of sleep disorders among women hospitalized with breast cancer, or their relationship to in-hospital outcomes. The present study represents a first step toward determining the clinical significance of sleep disorders for hospitalized breast cancer patients with regard to complications, length of hospital stay, and mortality. METHODS: The relationships between sleep disorders and in-hospital outcomes among 84,424 hospitalized breast cancer patients were examined. This study analyzed the Nationwide Inpatient Sample (NIS) database (2007 to 2011) for all women ages 40 years and older with a primary discharge diagnosis of breast cancer and a secondary discharge diagnosis of sleep disorder. Odds ratios, estimates, and 95% confidence intervals were computed using multivariable regression adjusting for age, comorbidities, race, cancer stage, income, insurance type, residential region, year of discharge, and surgical treatment type. RESULTS: Among women hospitalized with a primary diagnosis of breast cancer, 2% (n = 1807) also received a diagnosis of a sleep disorder during hospitalization, the majority of which were sleep-related breathing disorders (n = 1274). Although there was no significant association between having a diagnosis of a sleep disorder and in-hospital mortality, patients with a sleep disorder were more likely to also experience complications (OR = 1.58, 95% CI 1.29-1.34) and have longer hospital stays (mean = 0.44 days longer, 95% CI 0.25-0.63). CONCLUSION: Hospitalized breast cancer patients with a sleep disorder were more likely to experience clinical complications and stay longer in the hospital. It remains an open and important question for future research whether interventions to improve sleep during hospitalization would help to improve clinical outcomes.
PURPOSE: Sleep disturbances are recognized as a problem for many cancerpatients, but little is known about the prevalence of sleep disorders among women hospitalized with breast cancer, or their relationship to in-hospital outcomes. The present study represents a first step toward determining the clinical significance of sleep disorders for hospitalized breast cancerpatients with regard to complications, length of hospital stay, and mortality. METHODS: The relationships between sleep disorders and in-hospital outcomes among 84,424 hospitalized breast cancerpatients were examined. This study analyzed the Nationwide Inpatient Sample (NIS) database (2007 to 2011) for all women ages 40 years and older with a primary discharge diagnosis of breast cancer and a secondary discharge diagnosis of sleep disorder. Odds ratios, estimates, and 95% confidence intervals were computed using multivariable regression adjusting for age, comorbidities, race, cancer stage, income, insurance type, residential region, year of discharge, and surgical treatment type. RESULTS: Among women hospitalized with a primary diagnosis of breast cancer, 2% (n = 1807) also received a diagnosis of a sleep disorder during hospitalization, the majority of which were sleep-related breathing disorders (n = 1274). Although there was no significant association between having a diagnosis of a sleep disorder and in-hospital mortality, patients with a sleep disorder were more likely to also experience complications (OR = 1.58, 95% CI 1.29-1.34) and have longer hospital stays (mean = 0.44 days longer, 95% CI 0.25-0.63). CONCLUSION: Hospitalized breast cancerpatients with a sleep disorder were more likely to experience clinical complications and stay longer in the hospital. It remains an open and important question for future research whether interventions to improve sleep during hospitalization would help to improve clinical outcomes.
Entities:
Keywords:
Breast cancer; Complications; Inpatients; Mortality; Sleep disorders
Authors: Marina C Giménez; Leonie M Geerdinck; Mathijs Versteylen; Pieter Leffers; Gaby J B M Meekes; Hannelore Herremans; Boris de Ruyter; Jan Willem Bikker; Petra M J C Kuijpers; Luc J M Schlangen Journal: J Sleep Res Date: 2016-11-10 Impact factor: 3.981
Authors: Julie L Otte; Lorie Davis; Janet S Carpenter; Connie Krier; Todd C Skaar; Kevin L Rand; Michael Weaver; Carol Landis; Yelena Chernyak; Shalini Manchanda Journal: Support Care Cancer Date: 2016-05-04 Impact factor: 3.603
Authors: Tomi F Akinyemiju; Neomi Vin-Raviv; Daniel Chavez-Yenter; Xueyan Zhao; Henna Budhwani Journal: Cancer Epidemiol Date: 2015-07-29 Impact factor: 2.984
Authors: C Calderon; A Carmona-Bayonas; R Hernandez; B Castelo; S Varma; O Donnay; D Gomez; P Jimenez-Fonseca Journal: Clin Transl Oncol Date: 2019-02-02 Impact factor: 3.405
Authors: Hind A Beydoun; Jiu-Chiuan Chen; Nazmus Saquib; Michelle J Naughton; May A Beydoun; Aladdin H Shadyab; Lauren Hale; Alan B Zonderman Journal: J Affect Disord Date: 2022-06-22 Impact factor: 6.533
Authors: Hind A Beydoun; Sharmin Hossain; Shuyan Huang; May A Beydoun; Brook T Alemu; Shaker M Eid; Alan B Zonderman Journal: Psychosom Med Date: 2021-06-01 Impact factor: 3.864
Authors: Hind A Beydoun; Nazmus Saquib; Robert B Wallace; Jiu-Chiuan Chen; Mace Coday; Michelle J Naughton; May A Beydoun; Aladdin H Shadyab; Alan B Zonderman; Robert L Brunner Journal: Ann Clin Transl Neurol Date: 2022-06-24 Impact factor: 5.430
Authors: Chelsea G Ratcliff; Stephanie G Zepeda; Martica H Hall; Emily A Tullos; Shaelyn Fowler; Alejandro Chaoul; Amy Spelman; Banu Arun; Lorenzo Cohen Journal: Support Care Cancer Date: 2020-09-22 Impact factor: 3.603