Primary central nervous system germinal center B-like diffuse large B-cell lymphoma: a case report.

We report a case of a 54-year-old HIV-negative female who presented with a 2-month history of ongoing post meridiem low-level fever and new onset progressive paralysis. On MRI (magnetic resonance imaging), an infiltrative enhancing lesion was noted, which initially resembled that of MS, but she reacted not sensitively with immunosuppressive therapy, we performed a brain biopsy to her, it turned out to be primary CNS (central nervous system) diffuse large B-cell lymphoma (DLBCL). And the morphology, the flow cytometric findings were consistent with germinal center B-like diffuse large B-cell lymphoma. There were only a few case reports concerning primary CNS DLBCL of GCB. The misdiagnose of this patient should alarm the bell, and we should consider biopsy when the lesion is near the cortex in the brain. Why she reacted not sensitively with immunosuppressive therapy later is analyzed.