Narlon C Boa Sorte Silva1, Dawn P Gill2, Michael A Gregory3, John Bocti1, Robert J Petrella4. 1. School of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada. 2. Lawson Health Research Institute, London, ON, Canada; Health & Rehabilitation Sciences, Faculty of Health Sciences, Western University, London, ON, Canada; School of Health Studies, Faculty of Health Sciences, Western University, London, ON, Canada; Biomedical Sciences, Faculty of Medicine, University of Montreal, Montreal, QC, Canada. 3. Lawson Health Research Institute, London, ON, Canada; Health & Rehabilitation Sciences, Faculty of Health Sciences, Western University, London, ON, Canada; Cognitive Health and Aging Research Lab, Montreal Heart Institute, Montreal, QC, Canada; Biomedical Sciences, Faculty of Medicine, University of Montreal, Montreal, QC, Canada. 4. School of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Health & Rehabilitation Sciences, Faculty of Health Sciences, Western University, London, ON, Canada; Centre for Studies in Family Medicine, Department of Family Medicine, Western University, London, ON, Canada; Canadian Centre for Activity and Aging, Western University, London, ON, Canada. Electronic address: Robert.Petrella@schulich.uwo.ca.
Abstract
OBJECTIVE: To investigate the effects of multiple-modality exercise with or without additional mind-motor training on mobility outcomes in older adults with subjective cognitive complaints. METHODS: This was a 24-week randomized controlled trial with a 28-week no-contact follow-up. Community-dwelling older adults underwent a thrice -weekly, Multiple-Modality exercise and Mind-Motor (M4) training or Multiple-Modality (M2) exercise with an active control intervention (balance, range of motion and breathing exercises). Study outcomes included differences between groups at 24weeks and after the no-contact follow-up (i.e., 52weeks) in usual and dual-task (DT, i.e., serial sevens [S7] and phonemic verbal fluency [VF] tasks) gait velocity, step length and cycle time variability, as well as DT cognitive accuracy. RESULTS:127 participants (mean age 67.5 [7.3] years, 71% women) were randomized to either M2 (n=64) or M4 (n=63) groups. Participants were assessed at baseline, intervention endpoint (24weeks), and study endpoint (52weeks). At 24weeks, the M2 group demonstrated greater improvements in usual gait velocity, usual step length, and DT gait velocity (VF) compared to the M4 group, and no between- or within-group changes in DT accuracy were observed. At 52weeks, the M2 group retained the gains in gait velocity and step length, whereas the M4 group demonstrated trends for improvement (p=0.052) in DT cognitive accuracy (VF). CONCLUSIONS: Our results suggest that additional mind-motor training was not effective to improve mobility outcomes. In fact, participants in the active control group experienced greater benefits as a result of the intervention.
RCT Entities:
OBJECTIVE: To investigate the effects of multiple-modality exercise with or without additional mind-motor training on mobility outcomes in older adults with subjective cognitive complaints. METHODS: This was a 24-week randomized controlled trial with a 28-week no-contact follow-up. Community-dwelling older adults underwent a thrice -weekly, Multiple-Modality exercise and Mind-Motor (M4) training or Multiple-Modality (M2) exercise with an active control intervention (balance, range of motion and breathing exercises). Study outcomes included differences between groups at 24weeks and after the no-contact follow-up (i.e., 52weeks) in usual and dual-task (DT, i.e., serial sevens [S7] and phonemic verbal fluency [VF] tasks) gait velocity, step length and cycle time variability, as well as DT cognitive accuracy. RESULTS: 127 participants (mean age 67.5 [7.3] years, 71% women) were randomized to either M2 (n=64) or M4 (n=63) groups. Participants were assessed at baseline, intervention endpoint (24weeks), and study endpoint (52weeks). At 24weeks, the M2 group demonstrated greater improvements in usual gait velocity, usual step length, and DT gait velocity (VF) compared to the M4 group, and no between- or within-group changes in DT accuracy were observed. At 52weeks, the M2 group retained the gains in gait velocity and step length, whereas the M4 group demonstrated trends for improvement (p=0.052) in DT cognitive accuracy (VF). CONCLUSIONS: Our results suggest that additional mind-motor training was not effective to improve mobility outcomes. In fact, participants in the active control group experienced greater benefits as a result of the intervention.
Authors: Narlon C Boa Sorte Silva; Andrea F M Petrella; Nathan Christopher; Catherine F S Marriott; Dawn P Gill; Adrian M Owen; Robert J Petrella Journal: Front Aging Neurosci Date: 2021-04-15 Impact factor: 5.750
Authors: Narlon Cassio Boa Sorte Silva; Dawn P Gill; Adrian M Owen; Teresa Liu-Ambrose; Vladimir Hachinski; Ryosuke Shigematsu; Robert J Petrella Journal: PLoS One Date: 2018-04-26 Impact factor: 3.240
Authors: Narlon C Boa Sorte Silva; Lindsay S Nagamatsu; Dawn P Gill; Adrian M Owen; Robert J Petrella Journal: Front Aging Neurosci Date: 2020-02-25 Impact factor: 5.750