Literature DB >> 29261404

Hypothalamic GRP78, a new target against obesity?

Cristina Contreras1,2, Marcos F Fondevila1,2, Miguel López1,2.   

Abstract

The chaperone GRP78 (glucose related protein 78), also called BiP (binding immunoglobulin protein) is a key regulator of endoplasmic reticulum (ER) stress. We recently described that over-expression of GRP78 specifically in the ventromedial nucleus of the hypothalamus (VMH) releases hypothalamic ER stress in rodent obese models leading to weight loss, reduced hepatic steatosis and improved insulin and leptin sensitivity. The action of GRP78 is mediated by a feeding-independent mechanism involving increased sympathetic tone, augmented brown adipose tissue (BAT) thermogenesis and induction browning of white adipose tissue (WAT).

Entities:  

Keywords:  BAT; ER stress; GRP78; browning; hypothalamus; obesity; thermogenesis

Mesh：

Substances：

Year:  2017        PMID： 29261404      PMCID： PMC5915027          DOI： 10.1080/21623945.2017.1405878

Source DB:  PubMed          Journal:  Adipocyte        ISSN： 2162-3945            Impact factor:   4.534


  51 in total

1.  Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction.

Authors:  Yong Xu; Thekkethil P Nedungadi; Liangru Zhu; Nasim Sobhani; Boman G Irani; Kathryn E Davis; Xiaorui Zhang; Fang Zou; Lana M Gent; Lisa D Hahner; Sohaib A Khan; Carol F Elias; Joel K Elmquist; Deborah J Clegg
Journal:  Cell Metab       Date:  2011-10-05       Impact factor: 27.287

2.  Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

Authors:  Umut Ozcan; Erkan Yilmaz; Lale Ozcan; Masato Furuhashi; Eric Vaillancourt; Ross O Smith; Cem Z Görgün; Gökhan S Hotamisligil
Journal:  Science       Date:  2006-08-25       Impact factor: 47.728

3.  Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Authors:  Sarah M Turpin; Hayley T Nicholls; Diana M Willmes; Arnaud Mourier; Susanne Brodesser; Claudia M Wunderlich; Jan Mauer; Elaine Xu; Philipp Hammerschmidt; Hella S Brönneke; Aleksandra Trifunovic; Giuseppe LoSasso; F Thomas Wunderlich; Jan-Wilhelm Kornfeld; Matthias Blüher; Martin Krönke; Jens C Brüning
Journal:  Cell Metab       Date:  2014-10-07       Impact factor: 27.287

Review 4.  Hypothalamic AMPK: a canonical regulator of whole-body energy balance.

Authors:  Miguel López; Rubén Nogueiras; Manuel Tena-Sempere; Carlos Diéguez
Journal:  Nat Rev Endocrinol       Date:  2016-05-20       Impact factor: 43.330

5.  IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.

Authors:  Eduardo R Ropelle; Marcelo B Flores; Dennys E Cintra; Guilherme Z Rocha; José R Pauli; Joseane Morari; Claudio T de Souza; Juliana C Moraes; Patrícia O Prada; Dioze Guadagnini; Rodrigo M Marin; Alexandre G Oliveira; Taize M Augusto; Hernandes F Carvalho; Lício A Velloso; Mario J A Saad; José B C Carvalheira
Journal:  PLoS Biol       Date:  2010-08-24       Impact factor: 8.029

6.  Cold-activated brown adipose tissue in healthy men.

Authors:  Wouter D van Marken Lichtenbelt; Joost W Vanhommerig; Nanda M Smulders; Jamie M A F L Drossaerts; Gerrit J Kemerink; Nicole D Bouvy; Patrick Schrauwen; G J Jaap Teule
Journal:  N Engl J Med       Date:  2009-04-09       Impact factor: 91.245

7.  Endoplasmic reticulum stress plays a central role in development of leptin resistance.

Authors:  Lale Ozcan; Ayse Seda Ergin; Allen Lu; Jason Chung; Sumit Sarkar; Duyu Nie; Martin G Myers; Umut Ozcan
Journal:  Cell Metab       Date:  2009-01-07       Impact factor: 27.287

Review 8.  The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling.

Authors:  Suneng Fu; Steven M Watkins; Gökhan S Hotamisligil
Journal:  Cell Metab       Date:  2012-05-02       Impact factor: 27.287

Review 9.  The mammalian unfolded protein response.

Authors:  Martin Schröder; Randal J Kaufman
Journal:  Annu Rev Biochem       Date:  2005       Impact factor: 23.643

10.  Hepatic p63 regulates steatosis via IKKβ/ER stress.

Authors:  Begoña Porteiro; Marcos F Fondevila; Teresa C Delgado; Cristina Iglesias; Monica Imbernon; Paula Iruzubieta; Javier Crespo; Amaia Zabala-Letona; Johan Fernø; Bárbara González-Terán; Nuria Matesanz; Lourdes Hernández-Cosido; Miguel Marcos; Sulay Tovar; Anxo Vidal; Julia Sánchez-Ceinos; Maria M Malagon; Celia Pombo; Juan Zalvide; Arkaitz Carracedo; Xabier Buque; Carlos Dieguez; Guadalupe Sabio; Miguel López; Patricia Aspichueta; María L Martínez-Chantar; Ruben Nogueiras
Journal:  Nat Commun       Date:  2017-05-08       Impact factor: 14.919
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  2 in total

1.  Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling.

Authors:  Yin Yao
Journal:  Mol Med Rep       Date:  2020-01-13       Impact factor: 2.952

2.  Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake.

Authors:  Laura Liñares-Pose; Eva Rial-Pensado; Ánxela Estévez-Salguero; Edward Milbank; Ismael González-García; Claudia Rodríguez; Patricia Seoane-Collazo; Noelia Martinez-Sánchez; Rubén Nogueiras; Dolores Prieto; Carlos Diéguez; Cristina Contreras; Miguel López
Journal:  Genes (Basel)       Date:  2018-07-17       Impact factor: 4.096
  2 in total

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