Literature DB >> 29260313

Post-operative cognitive decline (POCD) after gynaecologic surgery: current opinions and future applications.

Cristina Zarbo1, Michela Brivio2, Agostino Brugnera2, Chiara Malandrino3, Gaetano Trezzi3, Massimo Rabboni4, Emi Bondi4, Angelo Compare2, Luigi Frigerio3.   

Abstract

OBJECTIVE: Postoperative cognitive decline (POCD) is known to occur quite frequently after a cardiac surgery, especially in older population. Few studies specifically focused on its incidence and characteristics in gynecological setting.
METHODS: Current opinions and future applications of POCD studies in gynecological setting have been discussed. RESULT: There are still many questions and issues about POCD in gynecological setting that remain unanswered as well as numerous research fields that have not been still explored. In particular, from this article emerges the need of further studies in gynecological setting focusing on: (a) the evaluation of long-term effect of POCD (e.g. over 3 months after surgery); (b) elderly population; (c) a wide range of cognitive functions (memory, attention, concentration, orientation, etc.); (d) the evaluation of risk and protective factors for subsequent POCD development; (e) the relationships between POCD and previous psychological or neuroendocrine factors; (f) the difference on POCD outcomes between different anaesthesia and disorders.
CONCLUSION: Promoting studies on this topic is significant for the reduction of sociosanitary costs, mortality rates, social dependences and the likelihood of comorbidity.

Entities:  

Keywords:  Cognition; Cognitive decline; Gynecology; POCD; Surgery

Mesh:

Year:  2017        PMID: 29260313     DOI: 10.1007/s00404-017-4630-3

Source DB:  PubMed          Journal:  Arch Gynecol Obstet        ISSN: 0932-0067            Impact factor:   2.344


  2 in total

1.  SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus.

Authors:  Ji-Shi Ye; Lei Chen; Ya-Yuan Lu; Shao-Qing Lei; Mian Peng; Zhong-Yuan Xia
Journal:  CNS Neurosci Ther       Date:  2018-09-17       Impact factor: 5.243

2.  Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus.

Authors:  Ji-Shi Ye; Lei Chen; Ya-Yuan Lu; Shao-Qing Lei; Mian Peng; Zhong-Yuan Xia
Journal:  Oxid Med Cell Longev       Date:  2019-02-24       Impact factor: 6.543

  2 in total

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