Sangeetha Srinivasan1, Cirous Dehghani1,2,3, Nicola Pritchard1, Katie Edwards1, Anthony W Russell4,5, Rayaz A Malik6,7, Nathan Efron1. 1. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. 2. Commonwealth Scientific and Industrial Research Organisation (CSIRO), Parkville, Victoria, Australia. 3. Poostchi Eye Research Centre, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Princess Alexandra Hospital, Woolloongabba, Queensland, Australia. 5. School of Medicine, University of Queensland, Woolloongabba, Queensland, Australia. 6. Weill Cornell Medicine-Qatar, Education City, Doha, Qatar. 7. Central Manchester University Hospitals Foundation Trust, Manchester, United Kingdom.
Abstract
Purpose: To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR). Methods: Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), corneal nerve fiber tortuosity (CNFT), full retinal thickness, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), focal (FLV) and global loss volumes (GLV), hemoglobin A1c (HbA1c), nephropathy, neuropathy, and cardiovascular measures were examined. Results: The central zone (P = 0.174), parafoveal thickness (P = 0.090), perifovea (P = 0.592), RNFL (P = 0.866), GCC (P = 0.798), and GCC GLV (P = 0.338) did not differ significantly between the groups. In comparison to the control group, those with very mild NPDR and those with mild NPDR had significantly higher focal loss in GCC volume (P = 0.036). CNFL was significantly lower in those with mild NPDR (P = 0.004) in comparison to the control group and those with no DR. The CNBD (P = 0.094) and CNFT (P = 0.458) did not differ between the groups. Conclusions: Both corneal and retinal neuronal degeneration may occur in early stages of diabetic retinopathy. Further studies are required to examine these potential markers for neuronal degeneration in the absence of clinical signs of DR.
Purpose: To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR). Methods:Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), corneal nerve fiber tortuosity (CNFT), full retinal thickness, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), focal (FLV) and global loss volumes (GLV), hemoglobin A1c (HbA1c), nephropathy, neuropathy, and cardiovascular measures were examined. Results: The central zone (P = 0.174), parafoveal thickness (P = 0.090), perifovea (P = 0.592), RNFL (P = 0.866), GCC (P = 0.798), and GCC GLV (P = 0.338) did not differ significantly between the groups. In comparison to the control group, those with very mild NPDR and those with mild NPDR had significantly higher focal loss in GCC volume (P = 0.036). CNFL was significantly lower in those with mild NPDR (P = 0.004) in comparison to the control group and those with no DR. The CNBD (P = 0.094) and CNFT (P = 0.458) did not differ between the groups. Conclusions: Both corneal and retinal neuronal degeneration may occur in early stages of diabetic retinopathy. Further studies are required to examine these potential markers for neuronal degeneration in the absence of clinical signs of DR.
Authors: Huiyuan Hou; Takuhei Shoji; Linda M Zangwill; Sasan Moghimi; Luke J Saunders; Kyle Hasenstab; Elham Ghahari; Patricia Isabel C Manalastas; Tadamichi Akagi; Mark Christopher; Rafaella C Penteado; Robert N Weinreb Journal: Am J Ophthalmol Date: 2018-02-13 Impact factor: 5.258
Authors: Ziqi Tang; Ming Yan Chan; Wai Yin Leung; Ho Yeung Wong; Ching Man Ng; Victor T T Chan; Raymond Wong; Jerry Lok; Simon Szeto; Jason C K Chan; Clement C Tham; Tien Y Wong; Carol Y Cheung Journal: Eye (Lond) Date: 2020-06-24 Impact factor: 3.775