Miriam D Ismail1, Ihsan Ali1, Savannah Hatt1, Elizabeth A Salzman1, Anna W Cronenwett1, Carl F Marrs1, Alexander H Rickard1, Betsy Foxman2. 1. The Center for Molecular and Clinical Epidemiology of Infectious Diseases (MAC-EPID), Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI 48109, USA. 2. The Center for Molecular and Clinical Epidemiology of Infectious Diseases (MAC-EPID), Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI 48109, USA. Electronic address: bfoxman@umich.edu.
Abstract
OBJECTIVES: The aim of this study was to test the hypothesis that urinary tract infections (UTIs) caused by Escherichia coli of the sequence type 131 (ST131) lineage are more likely to recur than UTIs caused by other E. coli lineages. METHODS: Isolates from 221 young women with UTI caused by E. coli participating in a randomised controlled trial were used. Participants were followed for 6 months or until UTI recurrence. RESULTS: Sequence type was not associated with risk of recurrence. Isolates in the ST131 lineage were more resistant than other STs to quinolones (6.2% vs. 1.3%) but not trimethoprim/sulfamethoxazole (15.4% vs. 15.0%). CONCLUSIONS: These results do not support an increased risk of recurrent UTI among otherwise healthy women with UTI caused by E. coli ST131.
RCT Entities:
OBJECTIVES: The aim of this study was to test the hypothesis that urinary tract infections (UTIs) caused by Escherichia coli of the sequence type 131 (ST131) lineage are more likely to recur than UTIs caused by other E. coli lineages. METHODS: Isolates from 221 young women with UTI caused by E. coli participating in a randomised controlled trial were used. Participants were followed for 6 months or until UTI recurrence. RESULTS: Sequence type was not associated with risk of recurrence. Isolates in the ST131 lineage were more resistant than other STs to quinolones (6.2% vs. 1.3%) but not trimethoprim/sulfamethoxazole (15.4% vs. 15.0%). CONCLUSIONS: These results do not support an increased risk of recurrent UTI among otherwise healthy women with UTI caused by E. coli ST131.
Authors: Philipp Kohler; Aline Wolfensberger; Susanne Stampf; Andreas Brönnimann; Katia Boggian; Christian van Delden; Melody Favre; Cédric Hirzel; Nina Khanna; Stefan P Kuster; Oriol Manuel; Dionysios Neofytos; Silvio Ragozzino; Peter W Schreiber; Laura Walti; Nicolas J Mueller Journal: Antimicrob Resist Infect Control Date: 2021-03-07 Impact factor: 4.887