Literature DB >> 29258848

ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview.

Alexander Belyy1, Undine Mechold2, Louis Renault3, Daniel Ladant2.   

Abstract

ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivered into the eukaryotic target cells. Recently, filamentous actin was identified as the eukaryotic cofactor that stimulates specifically ExoY enzymatic activity by several orders of magnitude. In this review, we discuss recent advances in understanding the biochemistry of nucleotidyl cyclase activity of ExoY and its regulation by interaction with filamentous actin.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Actin; Bacterial protein toxin; ExoY; Pseudomonas aeruginosa; T3SS

Mesh：

Substances：

Year:  2017        PMID： 29258848     DOI： 10.1016/j.toxicon.2017.12.046

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  10 in total

Review 1.  Molecular Mechanisms Involved in Pseudomonas aeruginosa Bacteremia.

Authors:  Stéphane Pont; Manon Janet-Maitre; Eric Faudry; François Cretin; Ina Attrée
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

2.  The extreme C terminus of the Pseudomonas aeruginosa effector ExoY is crucial for binding to its eukaryotic activator, F-actin.

Authors:  Alexander Belyy; Ignacio Santecchia; Louis Renault; Blandine Bourigault; Daniel Ladant; Undine Mechold
Journal:  J Biol Chem       Date:  2018-10-30       Impact factor: 5.157

3.  Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin.

Authors:  Dorothée Raoux-Barbot; Alexander Belyy; Lina Worpenberg; Sabrina Montluc; Celia Deville; Véronique Henriot; Christophe Velours; Daniel Ladant; Louis Renault; Undine Mechold
Journal:  PLoS One       Date:  2018-11-12       Impact factor: 3.240

Review 4.  The Modes of Action of MARTX Toxin Effector Domains.

Authors:  Byoung Sik Kim
Journal:  Toxins (Basel)       Date:  2018-12-02       Impact factor: 4.546

Review 5.  Structural Biology and Molecular Modeling to Analyze the Entry of Bacterial Toxins and Virulence Factors into Host Cells.

Authors:  Irène Pitard; Thérèse E Malliavin
Journal:  Toxins (Basel)       Date:  2019-06-24       Impact factor: 4.546

6.  Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens.

Authors:  Alexander Belyy; Felipe Merino; Undine Mechold; Stefan Raunser
Journal:  Nat Commun       Date:  2021-11-16       Impact factor: 14.919

7.  Identification of Diverse Toxin Complex Clusters and an eCIS Variant in Serratia proteamaculans Pathovars of the New Zealand Grass Grub (Costelytra Giveni) and Manuka Beetle (Pyronota Spp.) Larvae.

Authors:  Mark R H Hurst; Amy Beattie; Aurelie Laugraud; Richard Townsend; Lesley Sitter; Chikako van Koten; Lincoln Harper
Journal:  Microbiol Spectr       Date:  2021-10-20

Review 8.  The Role of Pseudomonas aeruginosa Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction.

Authors:  Brant M Wagener; Ruihan Hu; Songwei Wu; Jean-Francois Pittet; Qiang Ding; Pulin Che
Journal:  Toxins (Basel)       Date:  2021-11-02       Impact factor: 5.075

Review 9.  High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents.

Authors:  Donghoon Kang; Liyang Zhang; Natalia V Kirienko
Journal:  mBio       Date:  2021-05-04       Impact factor: 7.867

10.  Revealing how an adenylate cyclase toxin uses bait and switch tactics in its activation.

Authors:  Natosha L Finley
Journal:  PLoS Biol       Date:  2018-02-27       Impact factor: 8.029
  10 in total

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