| Literature DB >> 29258817 |
Lukas Zimmermann1, Andrew Stephens1, Seung-Zin Nam1, David Rau1, Jonas Kübler1, Marko Lozajic1, Felix Gabler1, Johannes Söding2, Andrei N Lupas3, Vikram Alva4.
Abstract
The MPI Bioinformatics Toolkit (https://toolkit.tuebingen.mpg.de) is a free, one-stop web service for protein bioinformatic analysis. It currently offers 34 interconnected external and in-house tools, whose functionality covers sequence similarity searching, alignment construction, detection of sequence features, structure prediction, and sequence classification. This breadth has made the Toolkit an important resource for experimental biology and for teaching bioinformatic inquiry. Recently, we replaced the first version of the Toolkit, which was released in 2005 and had served around 2.5 million queries, with an entirely new version, focusing on improved features for the comprehensive analysis of proteins, as well as on promoting teaching. For instance, our popular remote homology detection server, HHpred, now allows pairwise comparison of two sequences or alignments and offers additional profile HMMs for several model organisms and domain databases. Here, we introduce the new version of our Toolkit and its application to the analysis of proteins.Keywords: HHblits; HHpred; MPI Bioinformatics Toolkit; remote homology detection; structure prediction
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Year: 2017 PMID： 29258817 DOI： 10.1016/j.jmb.2017.12.007
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469