To the Editor,Although the cardiac effects of invasive and noninvasive ventilation have previously been investigated separately (1), we aimed to investigate the right and left ventricular systolic and diastolic dimensions and functions of preterm infants who were treated with surfactant and who received mechanical ventilation support due to respiratory distress syndrome (RDS).Preterm infants with birth weight of ≤1500 g and/or born at ≤32 gestational weeks within the first 6 h of life and requiring mechanical ventilation for at least the first 24 h of life due to RDS were considered. The first echocardiographic evaluation of the infants was during invasive ventilation. The second echocardiographic evaluation was in nasal continuous positive airway pressure (NCPAP) 24 h after infants were extubated, and the positive end-expiratory pressure (PEEP) was 6 cmH2O. Forty infants were studied (22 males and 18 females); mean gestational age was 27.2±2.1 (mean±SD) weeks,and mean birth weight was 1050±270 (mean±SD) g. A significant decrease in systolic blood pressure was observed in infants with patent ductus arteriosus (PDA), but no change was observed in left ventricular sizes and functions. In addition, no significant change was observed in right ventricular functions and cardiac output (CO) and fractional shortening values. For this reason, PDA is thought to have no effect on ventricular functions.In preterm infants, incorrect measurements may be obtained due to paradoxical septal wall movements and left ventricular distortion due to right ventricular dominance. In healthy infants, right ventricular cavity dimension at end-diastole (RVEDd) and right ventricular cavity dimension at end-systole (RVESd) decrease in the first 2 days of life, and this is similar for ventilated infants (2). We found that RVEDd, RVESd, and CO values of infants followed up in mechanical ventilators were lower than those obtained in infants after taking them to NCPAP. This difference was due to a decrease in right ventricular function, which was in the first 2 days of life, and due to a negative effect on the right ventricular function, which was caused by severe RDS (3). All infants were monitored with the same PEEP value, and improvements were determined in the hemodynamic and echocardiographic evaluations during noninvasive ventilation. This situation may be related in the recovery of lung problems rather than in the PEEP effect.We did not find any difference in hemodynamic parameters in relation to PDA. We noticed that PDA was associated with an increase in left atrial diameter and decrease in aortic root diameter while on invasive and noninvasive ventilation. We hypothesized that PDA may not be clinically characterized in the first days after delivery as the flow through it is generally not turbulent, wherein, as no physical sign is audible, it was not statistically significant. We believe that the treatment of RDS rather than of PDA in the first days of life is better based on hemodynamic and echocardiographic findings.Mechanical ventilation reduces the right and left ventricular preload and improves the left ventricular afterload (4). Mechanical ventilation should be used with the most optimal methods possible and the lowest mean airway pressure value for preterm infants in the presence of RDS. Preterm infants should be extubated as soon as possible and should be tried to be made with noninvasive ventilation.