Literature DB >> 29256716

PMab-48 Recognizes Dog Podoplanin of Lymphatic Endothelial Cells.

Shinji Yamada1, Shunsuke Itai1, Mika K Kaneko1, Yukinari Kato1,2.   

Abstract

Podoplanin, a type I transmembrane glycoprotein, is a specific marker of lymphatic endothelial cells (LECs). Recently, we developed PMab-38, an anti-dog podoplanin monoclonal antibody that did not stain canine LECs. In this study, we newly developed PMab-48 against dog podoplanin. Immunohistochemical analysis revealed that PMab-48 reacts not only with canine squamous cell carcinoma cells but also with LECs of the normal colon. Therefore, PMab-48 may be useful in investigating the function of dog podoplanin in LECs.

Entities:  

Keywords:  dog podoplanin; immunohistochemistry; monoclonal antibody

Mesh：

Substances：

Year:  2017        PMID： 29256716     DOI： 10.1089/mab.2017.0053

Source DB:  PubMed          Journal:  Monoclon Antib Immunodiagn Immunother        ISSN： 2167-9436


  5 in total

1.  The mouse-canine chimeric anti-dog podoplanin antibody P38B exerts antitumor activity in mouse xenograft models.

Authors:  Yukinari Kato; Tomokazu Ohishi; Manabu Kawada; Naoya Maekawa; Satoru Konnai; Shunsuke Itai; Shinji Yamada; Mika K Kaneko
Journal:  Biochem Biophys Rep       Date:  2018-11-24

2.  PDPN Is Expressed in Various Types of Canine Tumors and Its Silencing Induces Apoptosis and Cell Cycle Arrest in Canine Malignant Melanoma.

Authors:  Masahiro Shinada; Daiki Kato; Satoshi Kamoto; Sho Yoshimoto; Masaya Tsuboi; Ryohei Yoshitake; Shotaro Eto; Namiko Ikeda; Kohei Saeki; Yuko Hashimoto; Yosuke Takahashi; James Chambers; Kazuyuki Uchida; Mika K Kaneko; Naoki Fujita; Ryohei Nishimura; Yukinari Kato; Takayuki Nakagawa
Journal:  Cells       Date:  2020-05-05       Impact factor: 6.600

3.  Phase I/II Clinical Trial of the Anti-Podoplanin Monoclonal Antibody Therapy in Dogs with Malignant Melanoma.

Authors:  Satoshi Kamoto; Masahiro Shinada; Daiki Kato; Sho Yoshimoto; Namiko Ikeda; Masaya Tsuboi; Ryohei Yoshitake; Shotaro Eto; Yuko Hashimoto; Yosuke Takahashi; James Chambers; Kazuyuki Uchida; Mika K Kaneko; Naoki Fujita; Ryohei Nishimura; Yukinari Kato; Takayuki Nakagawa
Journal:  Cells       Date:  2020-11-23       Impact factor: 6.600

4.  Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways.

Authors:  Kelly L Hamilton; Stephanie A Sheehan; Edward P Retzbach; Clinton A Timmerman; Garret B Gianneschi; Patrick J Tempera; Premalatha Balachandran; Gary S Goldberg
Journal:  J Cancer Res Clin Oncol       Date:  2020-11-17       Impact factor: 4.553

5.  Establishment of P38Bf, a Core-Fucose-Deficient Mouse-Canine Chimeric Antibody Against Dog Podoplanin.

Authors:  Yukinari Kato; Takuya Mizuno; Shinji Yamada; Takuro Nakamura; Shunsuke Itai; Miyuki Yanaka; Masato Sano; Mika K Kaneko
Journal:  Monoclon Antib Immunodiagn Immunother       Date:  2018-11
  5 in total

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