| Literature DB >> 29256616 |
Yayun Gu1, Xuri Wu1, Huan Liu1, Qi Pan1, Yijun Chen1.
Abstract
A photocontrollable biocatalyst was rationally designed by site-specifically linking a photoswitchable azobenzene derivative to the only cysteine residue in heparinase III mutant (K130C). Upon photoswitch, the enzymatic degradation of heparin could be artificially controlled to produce low molecular weight heparin with more uniform molecular weight and an increase in anticoagulant activity.Entities:
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Year: 2017 PMID： 29256616 DOI： 10.1021/acs.orglett.7b03340
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005