| Literature DB >> 29256371 |
Kristina A Pugh1, Kyle J Reitnauer2, Robyn B Lee3, William L Wilkins4, John H McDonough5, M Ross Pennington6, Samantha R Litvin6.
Abstract
In this study, we compared the plasma concentrations of meloxicam in pediatric rat pups (ages: 7, 14, 21, and 28 d) with those of young adult rats. Adult rats received 1.34 mg/kg SC meloxicam to determine the target peak plasma concentration (Cmax) for comparison with the pediatric animals. Pediatric rats received 1.34 mg/kg SC meloxicam, and in all age groups, Cmax met or exceeded that in adults (11.5 ±2.7 μg/mL). Plasma concentrations were similar between male and female pups within age groups, and peak plasma concentration was achieved more rapidly in rat pups than adults. The analgesic efficacy of this dose was not evaluated in this study.Entities:
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Year: 2017 PMID： 29256371 PMCID： PMC5710155
Source DB: PubMed Journal: J Am Assoc Lab Anim Sci ISSN： 1559-6109 Impact factor: 1.232