Literature DB >> 29255124

Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.

Stephen L Archer1.   

Abstract

Entities:  

Keywords:  DNA methylation; Editorials; bone morphogenetic protein receptors, type II; extracellular signal-related MAP kinases; glycolysis

Mesh：

Substances：

Year:  2017        PMID： 29255124      PMCID： PMC5739072          DOI： 10.1161/CIRCULATIONAHA.117.031655

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


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4.  A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.

Authors:  John C Schell; Kristofor A Olson; Lei Jiang; Amy J Hawkins; Jonathan G Van Vranken; Jianxin Xie; Robert A Egnatchik; Espen G Earl; Ralph J DeBerardinis; Jared Rutter
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5.  Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

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6.  Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer.

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7.  FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.

Authors:  Lin Piao; Vaninder K Sidhu; Yong-Hu Fang; John J Ryan; Kishan S Parikh; Zhigang Hong; Peter T Toth; Erik Morrow; Shelby Kutty; Gary D Lopaschuk; Stephen L Archer
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8.  Bromodomain-Containing Protein 4: The Epigenetic Origin of Pulmonary Arterial Hypertension.

Authors:  Jolyane Meloche; François Potus; Mylène Vaillancourt; Alice Bourgeois; Ian Johnson; Laure Deschamps; Sophie Chabot; Grégoire Ruffenach; Sarah Henry; Sandra Breuils-Bonnet; Ève Tremblay; Valérie Nadeau; Caroline Lambert; Renée Paradis; Steeve Provencher; Sébastien Bonnet
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9.  Control of glioma cell death and differentiation by PKM2-Oct4 interaction.

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10.  Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

Authors:  Paola Caruso; Benjamin J Dunmore; Kenny Schlosser; Sandra Schoors; Claudia Dos Santos; Carol Perez-Iratxeta; Jessie R Lavoie; Hui Zhang; Lu Long; Amanda R Flockton; Maria G Frid; Paul D Upton; Angelo D'Alessandro; Charaka Hadinnapola; Fedir N Kiskin; Mohamad Taha; Liam A Hurst; Mark L Ormiston; Akiko Hata; Kurt R Stenmark; Peter Carmeliet; Duncan J Stewart; Nicholas W Morrell
Journal:  Circulation       Date:  2017-09-26       Impact factor: 29.690
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Review 4.  Vascular Metabolic Mechanisms of Pulmonary Hypertension.

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Review 5.  Epigenetic Inheritance Underlying Pulmonary Arterial Hypertension.

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6.  Flavopiridol Mitigates the Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Targeting Cyclin-Dependent Kinase 9.

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7.  Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra-coronary aortic banding.

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Review 8.  Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension.

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9.  Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.

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Review 10.  Molecular genetic framework underlying pulmonary arterial hypertension.

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