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Literature DB >> 2925508

L-671,329, a new antifungal agent. II. Structure determination.

C F Wichmann¹, J M Liesch, R E Schwartz.

Abstract

Based on spectroscopic data L-671,329, isolated from a filamentous fungus ATCC 20868, has been assigned the structure 1. The compound is a lipopeptide antifungal agent and a structural analog of echinocandin B.

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Year: 1989 PMID： 2925508 DOI： 10.7164/antibiotics.42.168

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

10 in total

1. Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.

Authors: D M Schmatz; M A Romancheck; L A Pittarelli; R E Schwartz; R A Fromtling; K H Nollstadt; F L Vanmiddlesworth; K E Wilson; M J Turner
Journal: Proc Natl Acad Sci U S A Date: 1990-08 Impact factor: 11.205

2. Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

Authors: M B Kurtz; C Douglas; J Marrinan; K Nollstadt; J Onishi; S Dreikorn; J Milligan; S Mandala; J Thompson; J M Balkovec
Journal: Antimicrob Agents Chemother Date: 1994-12 Impact factor: 5.191

3. Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.

Authors: M B Kurtz; I B Heath; J Marrinan; S Dreikorn; J Onishi; C Douglas
Journal: Antimicrob Agents Chemother Date: 1994-07 Impact factor: 5.191

4. Improvement in the titer of echinocandin-type antibiotics: a magnesium-limited medium supporting the biphasic production of pneumocandins A0 and B0.

Authors: J S Tkacz; R A Giacobbe; R L Monaghan
Journal: J Ind Microbiol Date: 1993-02

5. Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis.

Authors: C C Lawrence; W J Sobey; R A Field; J E Baldwin; C J Schofield
Journal: Biochem J Date: 1996-01-01 Impact factor: 3.857

6. In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin.

Authors: K Bartizal; G Abruzzo; C Trainor; D Krupa; K Nollstadt; D Schmatz; R Schwartz; M Hammond; J Balkovec; F Vanmiddlesworth
Journal: Antimicrob Agents Chemother Date: 1992-08 Impact factor: 5.191

L-671,329, a new antifungal agent. II. Structure determination.

1. Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.

2. Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

3. Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.

4. Improvement in the titer of echinocandin-type antibiotics: a magnesium-limited medium supporting the biphasic production of pneumocandins A0 and B0.

5. Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis.

6. In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin.

Review 7. Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides.

Review 8. Echinocandins: structural diversity, biosynthesis, and development of antimycotics.

Review 9. Metabolic engineering strategy for synthetizing trans-4-hydroxy-L-proline in microorganisms.

10. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli.