Ting Liu1, Hong Zhang2, Xuesong Yang3, Xiaojie Li4, Yi Shi5, Weidong Niu4, Tingjiao Liu6. 1. College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China; Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China. 2. College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China; The First Affiliated Hospital, Dalian Medical University, Dalian, China. 3. Department of Biochemistry and Molecular Biology, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian Medical University, China. 4. College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China. 5. West China School of Stomatology, Sichuan University, China. 6. College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China. Electronic address: tingjiao@dlmedu.edu.cn.
Abstract
OBJECTIVE: The aim of this study is to investigate the expressions of p16 and HPV16/18(E6) in oral lichen planus (OLP) and malignant transformed OLP (MT-OLP). STUDY DESIGN: The expression of p16 and HPV16/18(E6) in 40 cases of OLP and 6 MT-OLP was assessed by immunohistochemical staining. Twenty four cases of normal oral mucosa were used as controls. RESULTS: Compared to normal oral mucosa, the expression of p16 and HPV16/18(E6) protein increased in OLP and MT-OLP. And there was a correlation between p16 expression and HPV infection in OLP and OLP malignant lesions (p < 0.0001). CONCLUSIONS: The expression of p16 protein might predict HPV16/18 infection in OLP. And HPV16/18(E6) infection might contribute to OLP malignant transformation.
OBJECTIVE: The aim of this study is to investigate the expressions of p16 and HPV16/18(E6) in oral lichen planus (OLP) and malignant transformed OLP (MT-OLP). STUDY DESIGN: The expression of p16 and HPV16/18(E6) in 40 cases of OLP and 6 MT-OLP was assessed by immunohistochemical staining. Twenty four cases of normal oral mucosa were used as controls. RESULTS: Compared to normal oral mucosa, the expression of p16 and HPV16/18(E6) protein increased in OLP and MT-OLP. And there was a correlation between p16 expression and HPV infection in OLP and OLP malignant lesions (p < 0.0001). CONCLUSIONS: The expression of p16 protein might predict HPV16/18 infection in OLP. And HPV16/18(E6) infection might contribute to OLP malignant transformation.
Authors: Julia K Bar; Piotr Cierpikowski; Anna Lis-Nawara; Paula Duc; Agnieszka Hałoń; Małgorzata Radwan-Oczko Journal: Acta Otorhinolaryngol Ital Date: 2021-12 Impact factor: 2.124