| Literature DB >> 29254785 |
Cristina Pérez-Ramírez1, Marisa Cañadas-Garre2, Ahmed Alnatsha3, Eduardo Villar4, Juan Ramón Delgado5, Miguel Ángel Calleja-Hernández6, María José Faus-Dáder7.
Abstract
Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of ERCC1, ERCC2, ERCC5, XRCC1, XRCC3, MTHFR, MTR, MTHFD1, SLC19A1 and GSTP1 gene polymorphisms on risk of NSCLC. No association between these gene polymorphisms and susceptibility of NSCLC were found in our patients, suggesting that genetic variations in genes involved in DNA repair, folate and glutathione metabolism pathways may not influence the risk of NSCLC.Entities:
Keywords: DNA repair pathway; Folate metabolism pathway; Glutathione metabolism pathway; Non-small cell lung cancer; Polymorphisms; Risk
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Year: 2017 PMID： 29254785 DOI： 10.1016/j.prp.2017.11.015
Source DB: PubMed Journal: Pathol Res Pract ISSN： 0344-0338 Impact factor: 3.250